Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

Part of paid clinical trials in Columbia, Missouri.

Sponsor
University of Missouri-Columbia
Study ID
NCT06787066
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Propranolol Hydrochloride — DRUG
    Examine how IV propranolol impacts sympathetic transduction
  • Phentolamine Injection — DRUG
    Examine how IV phentolamine impacts sympathetic transduction

Study Details

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Key Dates

Start date
Jul 10, 2025
Status verified
Sep 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Women
    Women ages 18-70 years will participate.

Primary Outcome Measure

Sympathetic transduction [ Time Frame: 1 day (single study visit) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MissouriColumbiaMissouri65211
Jacqueline Limberg
[email protected]
573-882-2544

Find similar trials in Columbia, MO

By condition
Menopause
By specialty
Women's healthFertility
By research site
University of Missouri· Columbia, MO

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