The Effects of Repeated Operational Stress and Limited Recovery on Resilience Capacity

Part of paid clinical trials in Natick, Massachusetts.

Sponsor
United States Army Research Institute of Environmental Medicine
Study ID
NCT06784544
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Energy Deficit
  • High Physical Activity
  • Iron Absorption
  • Sleep, Inadequate

Eligibility Criteria

Sex
ALL
Age
17 Years - 39 Years
Healthy Volunteers
Accepted

Interventions

  • Operational Stressors — OTHER
    Intervention consists of a 48 hour energy balance phase preceding two rounds of repeated 72 hour energy deficit exposure each immediately followed by a 48h recovery phase. Balance and recovery phases will meet 100% of baseline energy requirements. Energy deficit phases will include an approximate 60% energy deficit of total daily energy requirements achieved through both a reduction in dietary intake and increased energy expenditure through physical activity.

Study Details

This longitudinal study will examine the effects of repeated bouts of operational stress and limited recovery on integrated MPS, whole-body protein balance, iron absorption, and aerobic performance. Following baseline characterization measures, active adults (n=24) representative of normal weight phenotype (NW; n=12) and overweight phenotype (OW; n=12) will complete a 48h balance phase preceding two rounds of repeated 72h energy deficit exposure each immediately followed by a 48h recovery phase. NW cutoff will be defined ≤ 22% body fat for males and ≤ 32% body fat for females. OW cutoff will be defined as \>22% body fat for males and \>32% body fat for females. These body composition cutoffs are informed by the maximum allowable percent body fat standards outlined in current Army Regulation 600-9. Additional details for determining % body fat are outlined in the experimental procedures section of the protocol.

Key Dates

Start date
May 31, 2025
Status verified
Jan 2025
Primary completion
Nov 30, 2025
Completion
Nov 30, 2025

Study Design

Enrollment
24 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active adults representative of overweight phenotype
    Active adults representative of overweight phenotype will complete a 48h balance phase followed by two rounds of repeated 72h energy deficit exposure, each immediately followed by a 48h recovery phase.
  • Active Comparator: Active adults representative of normal weight phenotype
    Active adults representative of normal weight phenotype will complete a 48h balance phase followed by two rounds of repeated 72h energy deficit exposure, each immediately followed by a 48h recovery phase.

Primary Outcome Measure

Integrated muscle protein synthesis [ Time Frame: Days 1-13 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
US Army Research Institute of Environmental MedicineNatickMassachusetts01760
Jess A Gwin, PhD
[email protected]
508-206-2300

Find similar trials in Natick, MA

By research site
US Army Research Institute of Environmental Medicine· Natick, MA

Related Studies