Impact of Sleep Duration on Immune Balance in Urban Children With Asthma

Conditions

• Asthma in Children
• Sleep Hygiene
• Sleep, Inadequate

Eligibility Criteria

Sex

ALL

Age

7 Years - 11 Years

Healthy Volunteers

Not accepted

Interventions

• Shortened Sleep — BEHAVIORAL
  In this experimental condition, children go to bed 90 minutes later than their typical bedtime during Week 2 of the 4-week protocol.
• Stabilized sleep — BEHAVIORAL
  In this control condition, children go to bed at their usual time throughout the 4-week protocol.

Study Details

Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management. Further, urban children with asthma suffer from altered immune balance, a key biological process contributing to individual differences in asthma morbidity and sleep health. In the proposed research, the researchers will examine the effects of shortened and recovery sleep on immune balance and associated changes in lung function in urban children with allergic asthma through an experimental design.

Key Dates

Start date

May 15, 2022

Status verified

Sep 2025

Primary completion

Jul 1, 2026

Completion

Jul 31, 2026

Study Design

Enrollment

204 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Arms

• Experimental: Shortened Sleep
  In this 4-week sleep protocol, children in this experimental condition follow a Stabilized Sleep schedule (i.e., their usual bed time) during weeks 1, 3 and 4. During week 2, they follow a Shortened Sleep schedule, during which they go to bed 90 later than is typical.
• Active Comparator: Usual Sleep Schedule
  In this control arm of the 4-week sleep protocol, children follow the Stabilized Sleep schedule for all 4 weeks.

Primary Outcome Measure

10mL of heparinized blood [ Time Frame: Changes in immune function across Days 7, 11, 14, 21 and 28 of the 4-week sleep protocol ]

Central Contacts

• Daphne Koinis-Mitchell, PhD
  401-793-8632
  [email protected]
• Sheryl J Kopel, MSc
  401 444-7217
  [email protected]

Locations (1)

Find similar trials in Providence, RI

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