Behavioral Pharmacology of Orally Administered THC and D-limonene

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT06378957
Phase
PHASE1
Status
Recruiting
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Conditions

  • D-limonene
  • Subjective Drug Effects
  • THC

Eligibility Criteria

Sex
ALL
Age
21 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • D-Limonene — DRUG
    Oral Limonene administered via capsule
  • Delta-9-THC — DRUG
    Oral delta-9-THC in ethanol vehicle administered via capsule
  • Placebo — DRUG
    Placebo (cellulose) administered via capsule

Study Details

The current clinical trial will investigate the effects of orally administered d-limonene (limonene), delta-9-tetrahydrocannabinol (THC) and the combination in healthy adult volunteers.

Key Dates

Start date
Feb 14, 2025
Status verified
May 2026
Primary completion
Jul 1, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
65 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Oral Placebo
    Placebo (cellulose), via capsule
  • Experimental: Oral THC 30mg
    30mg pure THC in ethanol vehicle, via capsule
  • Experimental: Oral THC 30mg + D-Limonene 25mg
    30mg pure THC in ethanol vehicle, via capsule 25mg pure D-Limonene, via capsule
  • Experimental: Oral THC 30mg + D-Limonene 50mg
    30mg pure THC in ethanol vehicle, via capsule 50mg pure D-Limonene, via capsule
  • Experimental: Oral THC 30mg + D-Limonene 100mg
    30mg pure THC in ethanol vehicle, via capsule 100mg pure D-Limonene, via capsule
  • Experimental: Oral THC 30mg + D-Limonene 200mg
    30mg pure THC in ethanol vehicle, via capsule 200mg pure D-Limonene, via capsule

Primary Outcome Measure

Subjective Drug Effect as assessed by Visual Analog Scale [ Time Frame: 8 hours after dosing ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Johns Hopkins Behavioral Pharmacology Research UnitBaltimoreMaryland21224
Austin Zamarripa
Austin Zamarripa, PhD (PRINCIPAL_INVESTIGATOR)

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