Pilot fMRI Studies of Aging-Related Effects of THC

Part of paid clinical trials in Hartford, Connecticut.

Sponsor
Yale University
Study ID
NCT06647524
Phase
PHASE2
Status
Recruiting
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Conditions

  • THC

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • THC — DRUG
    Participants will be administered 0.5g of vaporized THC cannabis (12% THC cannabis)
  • Placebo — DRUG
    Participants will be administered identical plant material from which all THC has been removed by solvent extraction.

Study Details

The purpose of this study is to begin investigating acute impairment of various forms of memory and learning by Tetrahydrocannabinol (THC) in cannabis (CNB) compared to placebo, in a 2-session per subject double-blind, random assignment, placebo-controlled counterbalanced design in young to middle-aged adults.

Key Dates

Start date
Jul 1, 2025
Status verified
Oct 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: THC then Placebo
    Participants in this arm will receive THC then placebo in a 2-session per subject double-blind, random assignment, placebo-controlled counterbalanced design. (Participants randomized to receive THC in the first session will receive placebo at the 2nd session.) Sessions will be scheduled at least one week apart. Tasks tapping each of the major cognitive memory-related domains will be performed in the MRI scanner, to reveal the relevant underlying circuitry and its disruption by drug using functional MRI.
  • Placebo Comparator: Placebo then THC
    Participants in this arm will receive placebo then THC in a 2-session per subject double-blind, random assignment, placebo-controlled counterbalanced design. (Participants randomized to receive placebo in the first session will receive THC at the 2nd session.) Sessions will be scheduled at least one week apart. Tasks tapping each of the major cognitive memory-related domains will be performed in the MRI scanner, to reveal the relevant underlying circuitry and its disruption by drug using functional MRI.

Primary Outcome Measure

The Complex Working Memory Span (CWMS) Task- Items Recalled [ Time Frame: At sessions 1 and 2 while under fMRI, immediately post drug administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Olin Neuropsychiatric Research Center at Hartford HealthcareHartfordConnecticut06106-

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Olin Neuropsychiatric Research Center at Hartford Healthcare· Hartford, CT

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