Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks

Part of paid clinical trials in West Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT05641766
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • THC

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • THC — DRUG
    Participants will receive THC into a rapidly flowing IV infusion.
  • Placebo — OTHER
    Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective/behavioral effects.

Study Details

The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.

Key Dates

Start date
Aug 31, 2025
Status verified
Jun 2025
Primary completion
Dec 1, 2025
Completion
Dec 1, 2025

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: THC
    Participants will receive THC into a rapidly flowing IV infusion.
  • Other: Placebo
    Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective/behavioral effects.

Primary Outcome Measure

Changes in brain dynamics during the Sternberg Working Memory Task [ Time Frame: Baseline and starting at +15 minutes after start of IV THC or placebo administration ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
VA Connecticut Healthcare System, Yale School of MedicineWest HavenConnecticut06516
Jose Cortes-Briones, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
VA Connecticut Healthcare System, Yale School of Medicine· West Haven, CT

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