Neural Correlates During Alcohol Intoxication

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT06118580
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Alcohol (Ethanol) — DRUG
    95% Ethanol diluted in Grape-flavored drink
  • Placebo — DRUG
    Grape-flavored drink

Study Details

Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and impaired executive function have been identified as key factors. Both Alcohol Use Disorder (AUD) and Impulsive Aggression behavior (AGG) are related to impaired social-emotional information processing (SEIP) whereby social threat cues, especially ones that are ambiguous in nature, lead to hostile attribution and negative emotional response to the "other" and, then, aggression against the "other". Thus, understanding the underlying neuroscience of SEIP under the influence of alcohol will be critical to identifying targets for intervention to reduce alcohol-related aggressive behavior. In addition to potential pharmacologic and cognitive-behavioral based interventions, such interventions may also involve the rehabilitation of aberrant neuronal circuits underlying social cognitive function through neuroplasticity-based remediation exercises. This study is designed to see how brain activation of cortico-limbic circuits involving social-emotional information processing, analyzed by fMRI Imaging, are impacted by alcohol administration in those with and without aggressive disorders and with and without alcohol use disorder.

Key Dates

Start date
Jun 8, 2023
Status verified
Mar 2025
Primary completion
Aug 31, 2025
Completion
Aug 31, 2026

Study Design

Enrollment
144 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Oral alcohol drink
  • Placebo Comparator: Placebo (non-alcohol drink)

Primary Outcome Measure

Cortico-limbic Response to Anger Faces [ Time Frame: 60-120 minutes after Ethanol (or Placebo) drink ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Ohio State University Wexner Medical CenterColumbusOhio43210
Emil Coccaro, M.D.
[email protected]
773-853-1338

Find similar trials in Columbus, OH

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
The Ohio State University Wexner Medical Center· Columbus, OH

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