Effect of Nitrous Oxide on Aggression.

Part of paid clinical trials in Columbus, Ohio.

Sponsor
Ohio State University
Study ID
NCT06118567
Phase
PHASE2
Status
Recruiting
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Conditions

  • Intermittent Explosive Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Nitrous oxide — DRUG
    Nitrous oxide gas.
  • Room Air — DRUG
    Room Air

Study Details

The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another session) and then undergo an fMRI scan 24 hours later. Researchers will compare healthy controls and impulsively aggressive individuals to see if Nitrous Oxide can normalize the function of cortico-limbic circuits in the latter group.

Key Dates

Start date
Sep 6, 2022
Status verified
Mar 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Nitrous Oxide Inhalation
    60 minute session inhaling Nitrous Oxide gas.
  • Sham Comparator: Room Air
    60 minute session inhaling Room Air.

Primary Outcome Measure

Cortico-Limbic Response to Anger Faces [ Time Frame: 24 hours after Nitrous Oxide and Room Air ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Ohio State University Wexner Medical CenterColumbusOhio43210-

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Ohio State University Wexner Medical Center· Columbus, OH

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