Impulsivity Domains and Subjective Response

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Jessica Weafer
Study ID
NCT05929677
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - 25 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo — DRUG
    Participants receive placebo (saline) intravenously. They will also have the opportunity to self-administer saline during the 60-minute free-access IV self-administration period in session 3.
  • Alcohol — DRUG
    Participants receive alcohol intravenously, clamped at BrACs of 20mg%, 40mg%, and 60mg%. They will also have the opportunity to self-administer alcohol (up to 120mg% BrAC) during the 60-minute free-access IV self-administration period in session 3.

Study Details

Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol. The results will identify badly needed, novel targets for prevention and treatment efforts to simultaneously reduce impulsivity and subjective responses in at-risk young adults.

Key Dates

Start date
Apr 1, 2024
Status verified
May 2026
Primary completion
Sep 1, 2027
Completion
Sep 1, 2027

Study Design

Enrollment
250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Alcohol, Then Placebo, then Free-access session
    participants will complete two intravenous administration sessions in the lab during which they will receive alcohol then placebo (saline), followed by a third lab session in which they will have free-access to self-administer alcohol (up to 120mg% BrAC) and placebo intravenously for 60 min
  • Experimental: Placebo, Then Alcohol, then Free-access session
    participants will complete two intravenous administration sessions in the lab during which they will receive placebo (saline) then alcohol, followed by a third lab session in which they will have free-access to self-administer alcohol (up to 120mg% BrAC) and placebo intravenously for 60 min

Primary Outcome Measure

Lab Subjective Response to Alcohol (SR) [ Time Frame: 70 minutes ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Northeastern UniversityBostonMassachusetts02115
Robert Leeman
[email protected]
617-373-6501
Ohio State UniversityColumbusOhio43221
Jessica Weafer, PhD
[email protected]
614-257-2075

Find similar trials in Boston, MA

By condition
Substance use disorder
By specialty
Behavioral healthAddiction medicine
By research site
Northeastern University· Boston, MAOhio State University· Columbus, OH

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