A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Part of paid clinical trials in Anniston, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT05929079
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC
  • Placebo — DRUG
    Administered SC

Study Details

The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study will last about 89 weeks and will include up to 24 visits.

Key Dates

Start date
Jul 11, 2023
Status verified
Apr 2026
Primary completion
May 31, 2026
Completion
May 31, 2026

Study Design

Enrollment
1,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose 1
    Participants will receive retatrutide subcutaneously (SC).
  • Experimental: Retatrutide Dose 2
    Participants will receive retatrutide SC.
  • Experimental: Retatrutide Dose 3
    Participants will receive retatrutide SC.
  • Placebo Comparator: Placebo
    Participants will receive placebo.

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 80 ]

Locations (40)

FacilityCityStateZIPSite coordinators
Pinnacle Research Group, LLCAnnistonAlabama36207-
Cullman Clinical TrialsCullmanAlabama35055-
Preferred Research PartnersLittle RockArkansas72211-
Core Healthcare GroupCerritosCalifornia90703-
Velocity Clinical Research, WestlakeLos AngelesCalifornia90057-
Valley Clinical Trials, Inc.NorthridgeCalifornia91325-
Diablo Clinical Research, Inc.Walnut CreekCalifornia94598-
Chase Medical Research, LLCWaterburyConnecticut06708-
Excel Medical Clinical TrialsBoca RatonFlorida33434-
Teradan Clinical Trials, LLCBrandonFlorida33511-
Fleming Island Center for Clinical ResearchFleming IslandFlorida32003-
Therafirst Medical CenterFort LauderdaleFlorida33308-
Clinical Site Partners LLC, dba Flourish ResearchMiamiFlorida33186-
Quantum Clinical TrialsMiami BeachFlorida33140-
Renstar Medical ResearchOcalaFlorida34470-
Clinical Research Center of FloridaPompano BeachFlorida33060-
Palm Beach Research CenterWest Palm BeachFlorida33409-
Clinical Site Partners, LLC dba Flourish ResearchWinter ParkFlorida32789-
NeuroTrials Research IncAtlantaGeorgia30328-
Centricity Research Rincon PulmonologyRinconGeorgia31406-
East-West Medical Research InstituteHonoluluHawaii96814-
Brengle Family MedicineIndianapolisIndiana46260-
MedVadis Research CorporationWalthamMassachusetts02451-
StudyMetrix ResearchCity of Saint PetersMissouri63303-
Las Vegas Medical ResearchLas VegasNevada89128-
Mid Hudson Medical ResearchNew WindsorNew York12553-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Carteret Medical GroupMorehead CityNorth Carolina28557-
Lillestol ResearchFargoNorth Dakota58104-
CTI Clinical Research CenterCincinnatiOhio45212-
Intrepid ResearchCincinnatiOhio45245-
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)PittsburghPennsylvania15236-
Preferred Primary Care PhysiciansUniontownPennsylvania15401-
Tribe Clinical Research, LLCGreenvilleSouth Carolina29607-
Trial Management AssociatesMyrtle BeachSouth Carolina29572-
Tribe Clinical Research - SpartanburgSpartanburgSouth Carolina29301-
FutureSearch Trials of NeurologyAustinTexas78731-
Velocity Clinical Research, DallasDallasTexas75230-
Advanced Research InstituteOgdenUtah84405-
Northwest Clinical Research CenterBellevueWashington98007-

Find similar trials in Anniston, AL

By condition
Obesity / overweightType 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Pinnacle Research Group, LLC· Anniston, ALCullman Clinical Trials· Cullman, ALPreferred Research Partners· Little Rock, ARCore Healthcare Group· Cerritos, CAVelocity Clinical Research, Westlake· Los Angeles, CAValley Clinical Trials, Inc.· Northridge, CA

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