Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts Eye and Ear Infirmary
Study ID
NCT05150106
Status
Recruiting
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Conditions

  • Laryngeal Dystonia
  • Spasmodic Dysphonia
  • Tremor

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Clinical assessments of laryngeal function — OTHER
    Participants will undergo acoustic, aerodynamic, respiratory kinematic, nasoendoscopic, and laryngeal EMG recordings, as well as real-time MRI of the upper airway for comprehensive characterization of shared and distinct features of laryngeal dystonia and voice tremor.

Study Details

The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.

Key Dates

Start date
Nov 7, 2022
Status verified
Nov 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
165 participants (estimated)

Arms

  • Arm: Laryngeal dystonia
    Patients with laryngeal dystonia (or spasmodic dysphonia)
  • Arm: Voice tremor
    Patients with voice tremor (essential or dystonic)
  • Arm: Healthy controls
    Healthy research volunteers

Primary Outcome Measure

Differences in voice symptoms [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts Eye and Ear and University of UtahBostonMassachusetts02114
Kristina Simonyan, MD, PhD
[email protected]
617-573-6016
Julie Barkmeier-Kraemer, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Massachusetts Eye and Ear and University of Utah· Boston, MA

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