Brain-Computer Interfaces in Laryngeal Dystonia

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Kristina Simonyan
Study ID
NCT04421365
Status
Recruiting
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Conditions

  • Laryngeal Dystonia

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • neurofeedback brain-computer interface (BCI) — DEVICE
    The integrated components of BCI system include the high-density EEG, 3D-VR, and a built-in ML platform as a real-time neural signal decoder and neurofeedback controller.

Study Details

The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.

Key Dates

Start date
Apr 18, 2022
Status verified
Nov 2025
Primary completion
Aug 31, 2027
Completion
Aug 31, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Active Comparator: Active neurofeedback BCI
    Patients are presented with symptomatic speech and asymptomatic whisper and, using active EEG-based neurofeedback, are trained to correct their speech by matching their brain patterns to those of whisper. This training is expected to be effective for symptom improvement.
  • Sham Comparator: Sham neurofeedback BCI
    Patients are presented with symptomatic speech and asymptomatic whisper and, using sham EEG-based neurofeedback, are trained to correct their speech by matching their brain patterns to those of whisper. This training is expected not to be effective for symptom improvement.

Primary Outcome Measure

Changes in voice symptoms [ Time Frame: At the end of day 5 of the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts Eye and Ear InfirmaryBostonMassachusetts02114
Kristina Simonyan, MD, PhD
[email protected]
617-573-6016

Find similar trials in Boston, MA

By research site
Massachusetts Eye and Ear Infirmary· Boston, MA

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