Brain Networks in Dystonia

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Massachusetts Eye and Ear Infirmary
Study ID
NCT03042962
Status
Recruiting
Apply to this trial

Conditions

  • Blepharospasm Oromandibular Dystonia
  • Craniofacial Dystonia
  • Musician's Focal Hand Dystonia
  • Singer's Dystonia
  • Spasmodic Dysphonia
  • Writer's Cramp

Eligibility Criteria

Sex
ALL
Age
21 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • MRI — OTHER
    Functional and structural MRI of the brain will be conducted to identify disorder specific neural markers
  • Blood draw — PROCEDURE
    Blood samples will be collected, the DNA will be extracted and banked for genetic studies

Study Details

To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia. The goal of this study is to dissect the pathophysiological mechanisms underlying this clinical phenomenon using multi-level brain network analysis in patients with focal dystonia.

Key Dates

Start date
Aug 1, 2015
Status verified
Dec 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
141 participants (estimated)

Arms

  • Arm: Patients with dystonia and their unaffected relatives
    Patients with dystonia and their unaffected blood relatives will undergo MRI of the brain and blood draw.
  • Arm: Healthy volunteers
    Healthy subjects without any neurological, psychiatric or otolaryngological problems will undergo MRI of the brain and blood draw.

Primary Outcome Measure

Incidence of brain structural and functional changes [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Massachusetts Eye and EarBostonMassachusetts02114
Kristina Simonyan, MD, PhD
[email protected]
617-573-6016
Kristina Simonyan, MD, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Massachusetts Eye and Ear· Boston, MA

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