Gene Expression Changes In Young and Geriatric Skin

Part of paid clinical trials in Fairborn, Ohio.

Sponsor
Wright State University
Study ID
NCT03932162
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Aging
  • Insulin-like Growth Factor 1
  • UVB Phototherapy Burn

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Insulin-Like Growth Factor 1 — DRUG
    Growth factor protein
  • No Insulin-Lie Growth Factor 1 — OTHER
    No Insulin-Like Growth Factor 1 will be given.

Study Details

This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.

Key Dates

Start date
Sep 6, 2019
Status verified
Feb 2025
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
24 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Placebo Comparator: Young Adult
    One small area of skin will undergo treatment with a small amount of UVB.
  • Active Comparator: Geriatric Adult
    Four small areas will undergo injection of a small amount of IGF-1 drug and two will undergo injections with saline. Then the injected areas will be treated with a small amount of UVB.

Primary Outcome Measure

Change in expression genes involved in protecting skin cells from UVB damage in younger skin and geriatric skin injected with IGF-1 from baseline [ Time Frame: 2 Days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wright State PhysiciansFairbornOhio45324-

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Wright State Physicians· Fairborn, OH

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