Effectiveness of Fractionated Laser Resurfacing to Protect Geriatric Skin From Actinic Neoplasia

Part of paid clinical trials in Dayton, Ohio.

Sponsor
Wright State University
Study ID
NCT03906253
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Fractionated Laser Resurfacing — DEVICE
    A rejuvenating laser that makes tiny holes in the very superficial part of the skin.

Study Details

This study is following up on previous studies that have demonstrated that geriatric subjects respond different to ultraviolet B (UVB) light than young subjects. The treatment of geriatric skin with dermal rejuvenation therapies (dermabrasion, fractionated laser resurfacing) restores the appropriate UVB response. Ongoing studies have tested the ability of fractionated laser resurfacing (FLR) to assess how long this wounding effect lasts-and have found that this appears to be a durable response which lasts for at least two years. The findings that FLR protects geriatric skin at two years is the impetus for this study. This study is an interventional study to assess if FLR treatment of one forearm of geriatric subjects with multiple actinic keratosis will result in the short-term removal of actinic keratosis, and the long-term decrease in levels of future actinic keratosis and other non-melanoma skin cancers in comparison to the untreated arm. Study length and visit: The first part of the study is completed in 1 day then there are follow up visits at 90 days and every 6 months for 5 years.

Key Dates

Start date
Jan 10, 2018
Status verified
Mar 2025
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Factionated Laser Resurfacing - Right Arm
    Right forearm treatment of fractionated laser resurfacing.
  • Experimental: Factionated Laser Resurfacing - Left Arm
    Left forearm treatment of fractionated laser resurfacing.

Primary Outcome Measure

Change From Baseline in the Number of Actinic Keratosis due to FLR treatment. [ Time Frame: up to 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Dayton VA Medical CenterDaytonOhio45428-

Find similar trials in Dayton, OH

By condition
Skin cancer
By specialty
OncologySkin cancerDermatology
By research site
Dayton VA Medical Center· Dayton, OH

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