Treatment Outcomes With tDCS in Post-Stroke Aphasia

Part of paid clinical trials in Little Rock, Arkansas.

Sponsor
University of Arkansas
Study ID
NCT03929432
Status
Recruiting
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Conditions

  • Aphasia

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Active Transcranial Direct Current Stimulation with SLT — DEVICE
    Soterix Medical 1×1 transcranial Direct Current Stimulator for Clinical Trials (1x1 tDCS-CT). Excitatory stimulation to the left hemisphere will be achieved through a 1x1 montage utilizing two carbon-rubber electrodes and 5x7 EASY pad sponges (A-tDCS \[excitatory\]left target; C-tDCS \[inhibitory\]right hemisphere). Each PWA will have a unique 5-digit tDCS program code for each treatment phase. One code will instruct the 1x1 tDCS-CT to administer active stimulation as describe above (i.e., 1.5 mA for 20 min). The other will administer 1.5 mA for only a few seconds to simulate active stimulation. SLT will consist of Semantic Feature Analysis, Phonological Component Analysis, and Verb Network Strengthening Treatment
  • Sham Transcranial Direct Current Stimulation with SLT — DEVICE
    Control condition in which only SLT is administered.Participant receives 1.5 mA for only a few seconds to simulate active stimulation, then the stimulation will cease. SLT will consist of Semantic Feature Analysis, Phonological Component Analysis, and Verb Network Strengthening Treatment

Study Details

The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.

Key Dates

Start date
Sep 3, 2019
Status verified
Jul 2025
Primary completion
Aug 31, 2028
Completion
Dec 31, 2029

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Active tDCS (with Speech-Language Treatment)
    tDCS Stimulation Dose: 1.5 mA for 20-mins
  • Sham Comparator: Sham tDCS (with Speech-Language Treatment)
    No tDCS stimulation

Primary Outcome Measure

Change in correct naming of nouns on Philadelphia Naming Test. [ Time Frame: Immediately after 1st and 2nd treatment phases and at 10 follow up after study completion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Arkansas for Medical SciencesLittle RockArkansas72205
Dana Moser, PhD, CCC-SLP
[email protected]
501-603-1011
Portia Carr
[email protected]
501-603-1019
Dana Moser, PhD, CCC-SLP (PRINCIPAL_INVESTIGATOR)

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By research site
University of Arkansas for Medical Sciences· Little Rock, AR

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