Escitalopram and Language Intervention for Subacute Aphasia

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Johns Hopkins University
Study ID
NCT03843463
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Escitalopram 10mg — DRUG
    Escitalopram tablet
  • Placebo — DRUG
    Sugar pill manufactured to mimic escitalopram 10 mg tablet
  • Computer-delivered naming treatment — BEHAVIORAL
    15 45-minute sessions of computer-delivered naming treatment beginning two months following stroke

Study Details

In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).

Key Dates

Start date
Jul 18, 2021
Status verified
Sep 2025
Primary completion
Sep 18, 2026
Completion
Jan 18, 2027

Study Design

Enrollment
88 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Naming Treatment + Escitalopram
    10 mg escitalopram daily for three months (escalating from 5 mg per day for the first week and tapering to 5 mg per day for the last two weeks)
  • Placebo Comparator: Naming Treatment + Placebo
    10 mg placebo daily for three months

Primary Outcome Measure

Change in Philadelphia Naming Test short-form accuracy score [ Time Frame: Baseline, 1 week after computer-delivered naming treatment ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Johns Hopkins School of MedicineBaltimoreMaryland21287
Argye E Hillis, MD
410-812-6716
Catherine Kelly, MA
[email protected]
410-502-6045
Medical University of South CarolinaCharlestonSouth Carolina29425
Leo Bonilha
[email protected]
843-792-5044
Kelly Krajeck
[email protected]
(843) 792-0189
University of South CarolinaColumbiaSouth Carolina29208
Souvik Sen
[email protected]
803-545-6073
Leigh Ann Spell
[email protected]
(803) 777-2693

Find similar trials in Baltimore, MD

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Johns Hopkins School of Medicine· Baltimore, MDMedical University of South Carolina· Charleston, SCUniversity of South Carolina· Columbia, SC

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