Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.

Part of paid clinical trials in Albuquerque, New Mexico.

Sponsor
University of New Mexico
Study ID
NCT04432883
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
25 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Active Comparator: Experimental: Active cathodal tDCS + language training — DEVICE
    Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli. Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
  • Sham Comparator: Placebo cathodal tDCS + Speech and language — BEHAVIORAL
    Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .

Study Details

62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.

Key Dates

Start date
Oct 18, 2022
Status verified
May 2026
Primary completion
Mar 26, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Experimental: Active cathodal tDCS + Speech-language training
    In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of active tDCS (x 30 minutes of stimulation) combined with 1 hour simultaneous speech-language training on consecutive weekdays.
  • Sham Comparator: Comparator: Placebo cathodal tDCS + Speech-language training
    In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of sham tDCS (x 30 minutes sham) combined with 1 hour simultaneous speech-language training on consecutive weekdays..

Primary Outcome Measure

Picture Naming of trained items [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of New Mexico Center for Brain Recovery and RepairAlbuquerqueNew Mexico87106
Darbi Gill
[email protected]
505-925-4043

Find similar trials in Albuquerque, NM

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of New Mexico Center for Brain Recovery and Repair· Albuquerque, NM

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