REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Johns Hopkins University
Study ID
NCT05611918
Status
Enrolling By Invitation

Conditions

  • Clot (Blood); Brain
  • Clot Blood
  • Cognitive Decline
  • Cognitive Impairment
  • Hemorrhage
  • ICH
  • ICH - Intracerebral Hemorrhage
  • Intra Cerebral Hemorrhage
  • Memory Impairment
  • Motor Activity
  • Stroke
  • Survivorship

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation (MISTIE) III and ENRICH trials to identify specific cognitive and motor impairment and to perform RNA sequencing to evaluate for evidence of chronic inflammation. The investigators' expected sample size in 2022 accounts for mortality attrition of 10%/year.

Key Dates

Start date
May 23, 2023
Status verified
Jun 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
350 participants (estimated)

Primary Outcome Measure

To determine if surgical clot reduction after ICH reduces the risk of progressive cognitive decline. [ Time Frame: 24 months ]

Locations (26)

FacilityCityStateZIPSite coordinators
University of Alabama at BriminghamBirminghamAlabama35294-
Scripps HealthLa JollaCalifornia92037-
Dignity Health component - St. Joseph's Hospital and Medical CenterSacramentoCalifornia95819-
Stanford UniversityStanfordCalifornia94305-
Yale UniversityNew HavenConnecticut06511-
Mayo Clinic, JacksonvilleJacksonvilleFlorida32224-
CommonSpirit (formerly Mercy San Juan Medical Center; dignity health)ChicagoIllinois60606-
University of Illinois at ChicagoChicagoIllinois60607-
University of Kansas Medical CenterFairwayKansas66205-
University of LouisvilleLouisvilleKentucky40292-
Johns Hopkins HospitalBaltimoreMaryland21205-
University of Maryland BaltimoreBaltimoreMaryland21201-
University of MichiganAnn ArborMichigan48109-
Henry Ford Health SystemDetroitMichigan48202-
Hennepin Healthcare Research InstituteMinneapolisMinnesota55415-
Washington University in St. Louis, School of MedicineSt LouisMissouri63130-
Rutgers - Robert Wood Johnson Medical SchoolPiscatawayNew Jersey08854-
University of New MexicoAlbuquerqueNew Mexico87131-
Albert Einstein MontefioreThe BronxNew York10461-
Wake Forest University Health SciencesWinston-SalemNorth Carolina27157-
University of CincinnatiCincinnatiOhio45220-
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107-
Vanderbilt University Medical CenterNashvilleTennessee37232-
University of Texas, Houston Health Science CenterHoustonTexas77030-
University of Texas Health Science Center at San AntonioSan AntonioTexas78229-
Inova Health System FoundationFairfaxVirginia22042-

Find similar trials in Birmingham, AL

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Alabama at Brimingham· Birmingham, ALScripps Health· La Jolla, CADignity Health component - St. Joseph's Hospital and Medical Center· Sacramento, CAStanford University· Stanford, CAYale University· New Haven, CTMayo Clinic, Jacksonville· Jacksonville, FL

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