Inflammatory and Infectious Diseases of the Nervous System

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Study ID
NCT02435810
Status
Recruiting
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Conditions

  • Brain Disease

Eligibility Criteria

Sex
ALL
Age
2 Years - 110 Years
Healthy Volunteers
Not accepted

Study Details

Background: \- Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this. Researchers want to learn more about how diseases affect the brain and nerves to develop better tests and treatments. Objective: \- To learn more about how inflammation and infections hurt the brain and nervous system. Eligibility: \- People at least 2 years old with a diagnosis or suspected diagnosis of nervous system infection or inflammation. Design: * For some participants, a clinician outside of NIH will collect blood, tissue, and other samples. These will be sent to NIH and analyzed. * Other participants will have several visits to NIH. Children may not have all these tests. * Participants will have: * Medical history. * Physical and neurological exam. * Blood and urine samples collected. * Saliva collected. They will chew on a piece of sterile cotton for one minute. * Magnetic resonance imaging (MRI) scan. The scanner is a metal cylinder in a strong magnetic field. Participants will lie on a table that slides in and out of the cylinder. Participants will get a contrast agent through an intravenous (IV) catheter during the MRI. A needle will be used to guide a thin plastic tube (catheter) into an arm vein. * Lumbar puncture. Skin will be numbed and a needle will be inserted into the space between the bones in the back. Fluid will be removed. * Some participants may have optional study procedures. These may include eye tests, memory and thinking testing, tests with electrodes on the head, or skin biopsy.

Key Dates

Start date
May 6, 2015
Status verified
May 2026
Primary completion
Nov 29, 2026
Completion
Nov 29, 2026

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Family Member
    A family member of a patient with known or suspected infection or inflammation of the nervous system based on clinical or imaging data provided
  • Arm: Patient
    Patient with known or suspected infection or inflammation of the nervous system based on clinical or imaging data provided

Primary Outcome Measure

This is a natural history study of individual cases [ Time Frame: 12 months after the last participant is enrolled. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
National Institutes of Health Clinical CenterBethesdaMaryland20892
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
[email protected]
800-411-1222

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By research site
National Institutes of Health Clinical Center· Bethesda, MD

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