Brain disorders Clinical Trials in St Louis, MO

As of June 2026, 65 paid clinical trials are recruiting for Brain disorders in St Louis, Missouri. Brain disorder trials span neurodegenerative diseases, stroke, traumatic brain injury, and neuromuscular conditions — testing both pharmacologic and rehabilitative approaches to slow progression and improve function. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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65 clinical trials for Brain disorders

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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

for Tuberous Sclerosis Complex

11 locations incl. Birmingham

Sponsor: Darcy Krueger

Sex: All·Age: 1 Day - 6 Months

Code: NCT05104983·Phase 2·Recruiting

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Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

for Alzheimer Disease

1 location in St Louis

Sponsor: Tammie L. S. Benzinger, MD, PhD

Sex: All·Age: 18+

Code: NCT04579120·Recruiting

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Study in Parkinson Disease of Exercise

for Parkinson Disease

24 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT04284436·Recruiting

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

24 locations incl. Paradise Valley

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting

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Imaging Biomarkers in Preclinical and Symptomatic AD

for Alzheimer Disease

1 location in St Louis

Sponsor: Tammie L. S. Benzinger, MD, PhD

Sex: All·Age: 18+

Code: NCT04134923·Recruiting

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Trial-Ready Cohort-Down Syndrome (TRC-DS)

for Down Syndrome

18 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 25 - 55

Code: NCT04165109·Recruiting

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

10 locations incl. Phoenix

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting

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Intermuscular Coherence as a Biomarker for ALS

for Amyotrophic Lateral Sclerosis

4 locations incl. Irvine

Sponsor: University of Chicago

Sex: All·Age: 20 - 90·Accepts healthy volunteers

Code: NCT05104710·Recruiting

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F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (DIAN Project)

for Alzheimer Disease

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT02414178·Enrolling By Invitation

Study of Tau Imaging With the Use of [18F]MK-6240 Tracer

for Alzheimer Disease

1 location in St Louis

Sponsor: Tammie L. S. Benzinger, MD, PhD

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04104659·Enrolling By Invitation

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

12 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Stroke Thrombectomy and Aneurysm Registry

for Stroke

54 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting

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Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for Autoimmune Disease

Drug: Nivolumab

51 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03816345·Phase 1·Recruiting

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North American Prodromal Synucleinopathy Consortium

for REM Sleep Behavior Disorder

9 locations incl. Sun City

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT03623672·Enrolling By Invitation

Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Late Onset Alzheimer's Disease

for Alzheimer Disease

12 locations incl. Washington D.C.

Sponsor: Columbia University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT05010603·Recruiting

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F 18 T807 Tau PET Imaging of Alzheimer's Disease

for Alzheimer Disease

1 location in St Louis

Sponsor: Tammie L. S. Benzinger, MD, PhD

Sex: All·Age: 18+

Code: NCT02414347·Recruiting

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Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

for Parkinson's Disease

28 locations incl. Aliso Viejo

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT02071134·Recruiting

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Clinical Outcomes for Deep Brain Stimulation

for Parkinson Disease

1 location in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: All ages

Code: NCT03992625·Recruiting

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Dominantly Inherited Alzheimer Network (DIAN)

for Alzheimer's Disease

8 locations incl. Jacksonville

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00869817·Recruiting

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Conditions in Brain disorders (St Louis, MO)

Alzheimer's disease· 22 Stroke· 11 Parkinson's disease· 9 Dementia· 7 Multiple sclerosis· 7 ALS (amyotrophic lateral sclerosis)· 6 Epilepsy· 5 Mild cognitive impairment (MCI)· 3 Cognitive impairment / decline· 3 Traumatic brain injury (TBI)· 2 Myasthenia gravis· 2 Essential tremor· 1