Clinical Trials at Mayo Clinic in Rochester

As of June 2026, 426 paid clinical trials are recruiting at Mayo Clinic in Rochester, located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906, phone (507) 255-5123 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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426 clinical trials at Mayo Clinic in Rochester

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An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis

for Colorectal Carcinoma

4 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06557733·Phase 2·Recruiting

Apply to this trial

ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia

for Recurrent Waldenstrom Macroglobulinemia

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07420959·Phase 1, Phase 2·Not Yet Recruiting

An Investigational Scan (18F-DOPA PET/CT) for Improving the Clinical Management of Brain Tumors

for Malignant Brain Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06667726·Phase 2·Recruiting

Apply to this trial

A Screening Program to Improve the Early Detection of Sporadic Pancreatic Cancer in Individuals With a High-Risk of Developing Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50 - 85

Code: NCT07324096·Recruiting

Apply to this trial

Evaluation of Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients

for Anatomic Stage I Breast Cancer AJCC v8

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 50

Code: NCT07460752·Phase 2·Not Yet Recruiting

Comparing Acoustic Resonance Therapy (ART) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I)

for Chronic Insomnia Disorder

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 22+

Code: NCT07486882·Recruiting

Apply to this trial

A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects

for Exocrine Pancreatic Insufficiency

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07285863·Phase 4·Recruiting

Apply to this trial

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

for Respiratory Distress Syndrome, Newborn

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 32 Weeks - 41 Weeks·Accepts healthy volunteers

Code: NCT07344714·Recruiting

Apply to this trial

A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound

for Heart Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 15+

Code: NCT07351656·Recruiting

Apply to this trial

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

for Unipolar Depression

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT07266545·Phase 4·Recruiting

Apply to this trial

Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07477886·Recruiting

Apply to this trial

Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty

for Post Operative Pain

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07153003·Phase 4·Enrolling By Invitation

Magnetic Resonance Elastography to Monitor Response to Manual Therapy in Myofascial Pain

for Myofascial Pain Syndrome - Lower Back

2 locations incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07278570·Recruiting

Apply to this trial

Electronic Approach to the Human Massage Therapist

for Lower Back Pain

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07040397·Recruiting

Apply to this trial

AI-Guided Left Bundle Branch Area Pacing

for Heart Failure

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07206602·Recruiting

Apply to this trial

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

for Healthy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06220396·Recruiting

Apply to this trial

Ultrasound Microvessel Imaging for the Evaluation of Ovarian and Adnexal Lesions

for Female Reproductive System Adnexal Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT07280312·Recruiting

Apply to this trial

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

for Focal Epilepsy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT07012148·Recruiting

Apply to this trial

Mayo Clinic Precure - Prospective Study

for Genetic Predisposition

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07332598·Enrolling By Invitation

Home Transcranial Direct Current Stimulation (tDCS) to Enhance Functional Recovery

for Stroke

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07091396·Enrolling By Invitation

BLOOM: Pragmatic Feasibility Trial

for Sepsis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07287332·Recruiting

Apply to this trial

Oral Methadone in Cardiac Surgery

for Pain, Postoperative

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07221617·Phase 4·Recruiting

Apply to this trial

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

for WHO Grade 3 Glioma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06444412·Phase 2·Recruiting

Apply to this trial

Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

for Osteoarthritis Hand

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50+

Code: NCT07217405·Phase 4·Recruiting

Apply to this trial

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

70 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting

Apply to this trial

BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

Drug: Nivolumab

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07226856·Phase 2·Recruiting

Apply to this trial

Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients

for Melanoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07379138·Recruiting

Apply to this trial

Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for the Treatment of Patients With Gastric and Gastroesophageal Junction Adenocarcinoma at High Risk of Peritoneal Recurrence

for Clinical Stage I Gastric Cancer AJCC v8

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT07139951·Phase 2·Enrolling By Invitation

A Study Of MCG In Cardiac Amyloidosis

for Amyloidosis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07218705·Recruiting

Apply to this trial

A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke

for Ischemic Stroke

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07291024·Recruiting

Apply to this trial

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

for Ewing Sarcoma

2 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 2+

Code: NCT07188532·Recruiting

Apply to this trial

Impact of Physician Behavior on Cancer Distress

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07325006·Recruiting

Apply to this trial

24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients

for Open Angle Glaucoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07325240·Phase 4·Recruiting

Apply to this trial

Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma

for Barrett Esophagus

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07212491·Enrolling By Invitation

Voices: Messages of Wisdom and Hope in the Face of Illness

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07381179·Recruiting

Apply to this trial

A Mindfulness-Based Stress Reduction Program for Improving Mental Health Outcomes for Underserved Cancer Patients in Minnesota

for Hematopoietic and Lymphatic System Neoplasm

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT07291011·Recruiting

Apply to this trial

The Role of Islet GLP-1 in the Pathogenesis of Prediabetes

for PreDiabetes

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT06967558·Phase 2·Recruiting

Apply to this trial

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07083011·Phase 2·Recruiting

Apply to this trial

Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure

for Heart Failure Preserved Ejection Fraction

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07057323·Enrolling By Invitation

Offering HPV Self-Collection in Novel Healthcare Settings to Improve Uptake of Cervical Cancer Screening

for Cervical Carcinoma

1 location in Rochester

Sponsor: Mayo Clinic

Sex: Female·Age: 30 - 63·Accepts healthy volunteers

Code: NCT07186530·Enrolling By Invitation