Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Conditions

• Osteoarthritis Hand
• Osteoarthritis Wrist

Eligibility Criteria

Sex

ALL

Age

50 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Corticosteroid injection (CSI) — DRUG
  A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine: * 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Radiocarpal (RC) joint - 40 mg methylprednisolone/1 mL 1% lidocaine\* * Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\* * Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine * Interphalangeal (IP) joint - 10 mg methylprednisolone/0.25 mL 1% lidocaine
• Low-dose radiotherapy (LDRT) — RADIATION
  Subjects will be treated with low-dose radiotherapy of 300cGy in 6 fractions, 2-3 times per week on non-consecutive days. Non-responders to the initial LDRT treatment will receive a second treatment course of 300cGy in 6 fractions to be given 2-3 times per week on non-consecutive days.

Study Details

The purpose of this research is to compare low-dose radiotherapy to corticosteroid injection for treatment of hand/wrist osteoarthritis.

Key Dates

Start date

Dec 19, 2025

Status verified

Apr 2026

Primary completion

May 1, 2027

Completion

Oct 1, 2027

Study Design

Enrollment

165 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Low-dose radiotherapy (LDRT)
  Subjects will receive a total of six (6) low-dose radiotherapy (LDRT) treatments for hand osteoarthritis.
• Active Comparator: Corticosteroid injection (CSI)
  Subjects will receive standard of care corticosteroid injection (CSI) therapy for hand osteoarthritis.

Primary Outcome Measure

Change in Visual Analog Scale (VAS) score [ Time Frame: Baseline, monthly for 6 months post-intervention, 9 months post-intervention, 12 months post-intervention ]

Central Contacts

• Tochukwu Iyke-Nzeocha
  (507) 422-3201
  [email protected]
• Melissa Wang, M.A., CCRP
  (507) 266-6911
  [email protected]

Locations (1)

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