Oral Methadone in Cardiac Surgery

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT07221617
Phase
PHASE4
Status
Recruiting
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Conditions

  • Anesthesia
  • Cardiac Surgery
  • Pain, Postoperative

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Methadone, oral — DRUG
    Patients will receive 0.4mg/kg PO methadone immediately prior to transport to the operating room
  • Methadone, intravenously — DRUG
    Patients will receive 0.3mg/kg methadone intravenously after induction of general anesthesia

Study Details

The purpose of this study is to compare the effects of administration of oral methadone preoperatively and intravenous methadone upon induction of general anesthesia on postoperative pain for patients undergoing elective cardiac surgery.

Key Dates

Start date
Jan 13, 2026
Status verified
Jan 2026
Primary completion
Jun 30, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Intravenous methadone intraoperatively
    Subjects in the IV methadone arm will receive methadone intravenously during cardiac surgery
  • Experimental: Oral methadone, immediately prior to transport
    Subjects in the oral methadone arm will receive methadone orally prior to cardiac surgery

Primary Outcome Measure

Amount of opioid medication used 72 hours post-extubation [ Time Frame: From hospital admission for surgery to 72 hours after the patient is extubated postoperatively ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905
Anesthesia Clinical Research Unit
866-265-9263
Krishnan Ramanujan, M.D. (PRINCIPAL_INVESTIGATOR)

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By research site
Mayo Clinic in Rochester· Rochester, MN

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