Clinical Trials at Mayo Clinic

As of June 2026, 491 paid clinical trials are recruiting at Mayo Clinic, located at 5360 KINGSBURY PL NW, ROCHESTER, MN 55901-2192, phone (507) 284-2511 in Rochester, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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491 clinical trials at Mayo Clinic

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Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis.

for Eosinophilic Esophagitis (EoE)

2 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07358234·EARLY_Phase 1·Enrolling By Invitation

Evaluation of the Efficacy and Safety of Magnetic Resonance Angiography (MRA) Using Gadopiclenol Compared to Gadoterate Meglumine in the Assessment of Steno-occlusive Disease in Adult Patients With Suspected Vascular Disease

for Steno-occlusive Disease

6 locations incl. Los Angeles

Sponsor: Guerbet

Sex: All·Age: 18+

Code: NCT07348640·Phase 3·Not Yet Recruiting

Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

for Spinal Cord Injuries

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 75

Code: NCT07210437·Recruiting

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Integrated Therapies for Alcohol Use in Alcohol-associated Liver Disease (ITAALD) Trial

for Alcohol-associated Hepatitis

6 locations incl. Indianapolis

Sponsor: Samer Gawrieh

Sex: All·Age: 18 - 70

Code: NCT07060638·Phase 2·Recruiting

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68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease

for Crohn's Disease

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07273188·EARLY_Phase 1·Recruiting

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Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder

for Bipolar I Disorder

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT07213466·Phase 4·Recruiting

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Impact of 1 mg Osilodrostat Therapy on Mild Autonomous Cortisol Secretion (MACS)

for Mild Autonomous Cortisol Secretion

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07104812·Phase 2·Recruiting

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A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer

for Platinum-resistant Ovarian Cancer

6 locations incl. Springdale

Sponsor: Stemline Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT07226427·Phase 1·Recruiting

Apply to this trial

Prospective Familial Registry for Pancreas Research

for Family History of Pancreas Cancer

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07358208·Enrolling By Invitation

Satisfaction and Feasibility Evaluation of an Electronic Massager Compared to Massage Therapist-delivered Massage

for Massage Therapy

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07042776·Recruiting

Apply to this trial

Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

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Clinical Study Protocol for Cutaneous SCC for Immunocompromised Patients

for Squamous Cell Carcinoma

10 locations incl. Gilbert

Sponsor: Alpha Tau Medical LTD.

Sex: All·Age: 18+

Code: NCT06615635·Not Yet Recruiting

Renal Pelvic Denervation Pilot Trial

for Uncontrolled Hypertension

5 locations incl. Birmingham

Sponsor: Verve Medical, Inc

Sex: All·Age: 21 - 80

Code: NCT07005050·Recruiting

Apply to this trial

Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

16 locations incl. La Jolla

Sponsor: Madrigal Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT07335601·Phase 2·Recruiting

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Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

for Lupus Nephritis (LN)

2 locations incl. Rochester

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18 - 60

Code: NCT06975787·Phase 1·Recruiting

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The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.

for Metastatic Solid Tumors

1 location in Rochester

Sponsor: New Phase Ltd.

Sex: All·Age: 18+

Code: NCT07224464·Recruiting

Apply to this trial

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

for Focal Epilepsy

7 locations incl. Boise

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 70

Code: NCT07219407·Phase 2·Recruiting

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Accuracy of a Cuffless Photoplethysmography (PPG) Chest-Patch Monitor for 24-hour Ambulatory Blood Pressure Monitoring (ABPM)

for Blood Pressure

5 locations incl. Birmingham

Sponsor: Biobeat Technologies Ltd.

Sex: All·Age: 18+

Code: NCT07240831·Recruiting

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One vs. Two Stents for Gallbladder Disease

for Recurrent Cholecystitis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 95

Code: NCT07222527·Recruiting

Apply to this trial

Minimal Sedation During Knee Replacement Surgery

for Total Knee Arthroplasty

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07371390·Recruiting

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Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years

for Fuchs Endothelial Corneal Dystrophy

14 locations incl. Atlanta

Sponsor: Case Western Reserve University

Sex: All·Age: 30 - 93

Code: NCT07217249·Enrolling By Invitation

A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes

for Polycythemia Vera

1 location in Rochester

Sponsor: FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

Sex: All·Age: 18 - 100

Code: NCT07203768·Recruiting

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A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC

for Primary Sclerosing Cholangitis (PSC)

7 locations incl. Sacramento

Sponsor: LISCure Biosciences

Sex: All·Age: 18 - 75

Code: NCT06699121·Phase 2·Recruiting

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A Study of SCAD Using Stress Contrast Echocardiography

for Spontaneous Coronary Artery Dissection

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07178509·Recruiting

Apply to this trial

Automated Manual Lymphatic Drainage Therapy to Improve Glymphatic Function in OSA Patients

for Obstructive Sleep Apnea (OSA)

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50+

Code: NCT07301762·Enrolling By Invitation

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

for Metastatic Castration-resistant Prostate Cancer

13 locations incl. San Francisco

Sponsor: K36 Therapeutics, Inc.

Sex: Male·Age: 18+

Code: NCT07103018·Phase 1·Recruiting

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Carcinoid Syndrome Efficacy Study Featuring an Oral Daily Paltusotine Regimen

for Carcinoid Syndrome

17 locations incl. Gilbert

Sponsor: Crinetics Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT07087054·Phase 3·Recruiting

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Health and Wellness Coaching to Improve Thoracic Transplant Caregiver Self-Efficacy

for Wellbeing

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07361159·Recruiting

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Actinium Therapy for Late-stage Aggressive Sarcomas

for Advanced Soft Tissue Sarcoma

5 locations incl. Los Angeles

Sponsor: Ratio Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07156565·Phase 1·Recruiting

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Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

for Osteoarthritis Knee Pain

20 locations incl. San Diego

Sponsor: Saol Therapeutics Inc

Sex: All·Age: 40+

Code: NCT07226258·Phase 3·Recruiting

Apply to this trial

Smoking Cessation Trial in Recurrent Acute Pancreatitis and Chronic Pancreatitis

for Pancreatitis, Chronic

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07171112·Phase 2·Recruiting

Apply to this trial

Comparing the Safety and Efficacy of ASI-02 to Agitated Saline for Suspected Right-to-left Shunt

for Right-To-Left Shunt

5 locations incl. Chicago

Sponsor: Agitated Solutions, Inc.

Sex: All·Age: 18+

Code: NCT06938347·Phase 3·Recruiting

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Tau PET Outcomes With Anti-amyloid Immunotherapies

for Cognitive Impairment, Mild

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 50 - 90

Code: NCT06723015·Phase 2·Enrolling By Invitation

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting

Apply to this trial

BoxX-NoAF Clinical Trial

for Post Operative Atrial Fibrillation

14 locations incl. Jonesboro

Sponsor: AtriCure, Inc.

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06989775·Recruiting

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A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy

for Bone Cancer Metastatic

7 locations incl. San Diego

Sponsor: Society of Interventional Oncology

Sex: All·Age: 21+

Code: NCT06859801·Recruiting

Apply to this trial

ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

for Spinal Cord Injuries

12 locations incl. Little Rock

Sponsor: ONWARD Medical, Inc.

Sex: All·Age: 18 - 75

Code: NCT07147296·Recruiting

Apply to this trial

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

for Heart Failure With Preserved Ejection Fraction

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07093528·Recruiting

Apply to this trial

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography

for Amyloidosis

1 location in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 20+

Code: NCT07216469·Recruiting

Apply to this trial

Subcortical Arousal in Perceptual Awareness

for Epilepsy

8 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356·Recruiting

Apply to this trial