A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

Part of paid clinical trials in Boise, Idaho.

Sponsor
Rapport Therapeutics Inc.
Study ID
NCT07219407
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Epilepsy
  • Focal Epilepsy
  • Focal Onset Seizure
  • Focal Seizure
  • Refractory Focal Epilepsy
  • Seizure

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • RAP-219 — DRUG
    Participants will receive one RAP-219 0.125 mg capsule daily for 3 days followed by one 0.25mg tablet RAP-219 daily for 28 days, then one 0.75mg tablet daily for the remainder of the treatment period.

Study Details

This is a clinical research study for an investigational drug called RAP-219 in patients with Refractory Focal Epilepsy. This study is being conducted to determine RAP-219 Long- term safety and open-label antiseizure activity in patients with Refractory Focal Epilepsy.

Key Dates

Start date
Dec 15, 2025
Status verified
Jan 2026
Primary completion
Feb 3, 2028
Completion
Feb 3, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: RAP-219

Primary Outcome Measure

Incidence of treatment-emergent adverse events (TEAEs) [ Time Frame: From the start of RAP-219 treatment through 8 weeks after last dose, up to Week 112 ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Consultants in Epilepsy and Neurology, PLLCBoiseIdaho83702-
Mayo ClinicRochesterMinnesota55905-
NYU Langone Comprehensive Epilepsy CenterNew YorkNew York10016-
Cleveland Clinic FoundationClevelandOhio44195-
University of Pennsylvania - Department of NeurologyPhiladelphiaPennsylvania19104-
Vanderbilt University Medical CenterNashvilleTennessee37232-
Baylor College of MedicineHoustonTexas770300-

Find similar trials in Boise, ID

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Consultants in Epilepsy and Neurology, PLLC· Boise, IDMayo Clinic· Rochester, MNNYU Langone Comprehensive Epilepsy Center· New York, NYCleveland Clinic Foundation· Cleveland, OHUniversity of Pennsylvania - Department of Neurology· Philadelphia, PAVanderbilt University Medical Center· Nashville, TN

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