Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT07210437
Status
Recruiting
Apply to this trial

Conditions

  • Spinal Cord Injuries

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Tests of sympathetic inhibition — DIAGNOSTIC_TEST
    Bolus phenylephrine infusion using the Oxford technique will generate the need to inhibit sympathetic activity. Similarly, resting state Mayer waves will be assessed with regard to heart rate and blood pressure responses.
  • Tests of above level sympathetic activation — DIAGNOSTIC_TEST
    Cold pressor test of the hand will be used to cause sympathetic activation. Valsalva's maneuver will assess the ability to buffer against blood pressure fall (phase II).
  • Testing of below level sympathetic activation — DIAGNOSTIC_TEST
    Cold pressor test of the foot and bladder pressor response will be tested.

Study Details

The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.

Key Dates

Start date
Jan 31, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2027
Completion
Jun 1, 2028

Study Design

Enrollment
18 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Chronic Spinal Cord Injury
  • Experimental: Acute Spinal Cord Injury

Primary Outcome Measure

Valsalva Maneuver Phase II [ Time Frame: During laboratory diagnostic testing session ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo ClinicRochesterMinnesota55905
Erin Lund
[email protected]
507-284-9298
Ryan J. Solinsky, MD (PRINCIPAL_INVESTIGATOR)

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Mayo Clinic· Rochester, MN

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