Clinical Trials at University of Pennsylvania

As of June 2026, 377 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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377 clinical trials at University of Pennsylvania

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

Apply to this trial

SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

2 locations incl. Stanford

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting

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Cervical Ripening as an Outpatient Method Using the Foley (COMFORT)

for Induction of Labor Affected Fetus / Newborn

6 locations incl. Newark

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05759988·Recruiting

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SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

for Ovarian Cancer

5 locations incl. Tampa

Sponsor: Verismo Therapeutics

Sex: All·Age: 18+

Code: NCT05568680·Phase 1·Recruiting

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Cannabis Use and Outcomes in Black and White Patients With Cancer

for Cancer

3 locations incl. Buffalo

Sponsor: State University of New York at Buffalo

Sex: All·Age: 21 - 99

Code: NCT06037681·Recruiting

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Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)

for Alzheimer's Disease

2 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 120

Code: NCT05658913·Recruiting

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Reducing Patient Memory Recall in the Burning Mouth Patient Population

for Burning Mouth Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05819697·Recruiting

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Longitudinal Study for Central Nervous System Vasculitis

for Central Nervous System Vasculitis

4 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05734404·Recruiting

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HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

6 locations incl. Sacramento

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting

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A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma

13 locations incl. San Francisco

Sponsor: K36 Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05651932·Phase 1·Recruiting

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Decoding and Modulating Affective Brain States

for Rumination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05437705·Recruiting

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A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

9 locations incl. Chicago

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting

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A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

for Primary Generalized Tonic-Clonic Seizures

Drug: XEN1101

59 locations incl. Mobile

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT05667142·Phase 3·Recruiting

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Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

for Obstructive Sleep Apnea

2 locations incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 18 - 75

Code: NCT05742360·Recruiting

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Descemet Endothelial Thickness Comparison Trial II

for Fuchs

8 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT05275972·Phase 3·Recruiting

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

4 locations incl. Baltimore

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

for Urinary Bladder Neoplasms

41 locations incl. Tucson

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05614739·Phase 1·Recruiting

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PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

for Critical Limb Ischemia

30 locations incl. La Jolla

Sponsor: LimFlow, Inc.

Sex: All·Age: 18 - 95

Code: NCT05313165·Recruiting

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

14 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting

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Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal

for Liver Diseases

2 locations incl. Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18+

Code: NCT05470205·Phase 3·Recruiting

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Resting State Changes Following Theta Burst Stimulation

for Brain Connectivity

1 location in Philadelphia

Sponsor: Nicholas Balderston, PhD

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT05322239·Recruiting

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All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for Glioma

1 location in Philadelphia

Sponsor: Stephen Bagley, MD, MSCE

Sex: All·Age: 18+

Code: NCT05345002·Phase 2·Recruiting

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A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

for Advanced Cancer

15 locations incl. Los Angeles

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05557045·Phase 1·Recruiting

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A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus

for Subacute Cutaneous Lupus Erythematosus

61 locations incl. Anniston

Sponsor: Biogen

Sex: All·Age: 18+

Code: NCT05531565·Phase 2, Phase 3·Recruiting

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TVMR With the INNOVALVE System Trial - Early Feasibility Study

for Mitral Valve Regurgitation (Degenerative or Functional)

20 locations incl. Los Angeles

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04919980·Recruiting

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LCAT (Lecithin Cholesterol Acyl Transferase) Natural History Study

for LCAT Deficiency

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT06217588·Recruiting

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

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How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

for OCD

2 locations incl. New York

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45

Code: NCT05359562·Recruiting

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The Periviable GOALS Decision Support Tool

for Pregnancy Preterm

12 locations incl. San Diego

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT05264779·Recruiting

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Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

for Myelofibrosis

22 locations incl. Duarte

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT05320198·Phase 1, Phase 2·Recruiting

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Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

for Relapsed Adult AML

20 locations incl. Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05237258·Recruiting

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A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

for FSGS

54 locations incl. Birmingham

Sponsor: Dimerix Bioscience Pty Ltd

Sex: All·Age: 12 - 80

Code: NCT05183646·Phase 3·Recruiting

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

19 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting

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Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study

for Ovarian Cancer

9 locations incl. Boston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT05287451·Recruiting

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Immune Profiles in Multiple Sclerosis (MS) Patients and Healthy Volunteers Through Thoracic Duct Cannulation

for Multiple Sclerosis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT05162638·Enrolling By Invitation

Tadekinig Alfa (IL-18BP) Rescue Therapy for CAR T Cell Related Cytokine Release Syndrome (CRS) and HLH-like Syndrome

for CRS - Cytokine Release Syndrome

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05306080·EARLY_Phase 1·Recruiting

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Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology

for Semantic Dementia

5 locations incl. San Francisco

Sponsor: Peter Ljubenkov, MD

Sex: All·Age: 18 - 85

Code: NCT05184569·Phase 1·Recruiting

Apply to this trial

Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

4 locations incl. New Haven

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting

Apply to this trial