SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

Part of paid clinical trials in Tampa, Florida.

Sponsor
Verismo Therapeutics
Study ID
NCT05568680
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SynKIR-110, Autologous T cells Transduced with Mesothelin KIR-CAR — BIOLOGICAL
    Autologous T cells Transduced with Mesothelin KIR-CAR

Study Details

This first-in-human (FIH) trial is designed to assess the safety, feasibility, and potential activity of a single intravenous (IV) dose of SynKIR-110 administered to subjects with mesothelin-expressing advanced ovarian cancer, mesothelioma, and cholangiocarcinoma.

Key Dates

Start date
Mar 30, 2023
Status verified
Oct 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
42 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: SynKIR-110
    Single dose gravity drip IV administration

Primary Outcome Measure

Safety and Feasibility of SynKIR-110 [ Time Frame: Up to 12 months ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
Moffitt Cancer CenterTampaFlorida33612
Ashley O'Neil, MPH, LSSWB, CCRC
[email protected]
813-745-5240
Ben Creelan, MD (PRINCIPAL_INVESTIGATOR)
University of Kansas Cancer CenterWestwoodKansas66205
Nurse Navigation
[email protected]
913-945-7552
Raed Al-Rajabi, MD (PRINCIPAL_INVESTIGATOR)
University of PennsylvaniaPhiladelphiaPennsylvania19104
Andrea Standish
[email protected]
215-662-2419
Janos Tanyi, MD, PhD (PRINCIPAL_INVESTIGATOR)
MD Anderson Cancer CenterHoustonTexas77030
Zheng Zhang
[email protected]
832-729-0975
Mehmet Altan, MD (PRINCIPAL_INVESTIGATOR)
University of Wisconsin Carbone Cancer CenterMadisonWisconsin53792
Cancer Connect
[email protected]
800-622-8922
Zhubin Gahvari, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Tampa, FL

By condition
Ovarian cancer
By specialty
OncologyGynecologic oncologyWomen's health
By research site
Moffitt Cancer Center· Tampa, FLUniversity of Kansas Cancer Center· Westwood, KSUniversity of Pennsylvania· Philadelphia, PAMD Anderson Cancer Center· Houston, TXUniversity of Wisconsin Carbone Cancer Center· Madison, WI

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