As of June 2026, 146 paid clinical trials are recruiting for Oncology in Orange, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Orange has approximately 539 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Researchers run research studies in Orange, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Children's Hospital of Orange County | Recurrent Malignant Solid Neoplasm, B Acute Lymphoblastic Leukemia, Neuroblastoma | 76 |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Malignant Solid Neoplasm, Stage IV Colorectal Cancer AJCC v8 | 65 |
| University of California Irvine | Amyotrophic Lateral Sclerosis, Anticoagulants, Carcinoma, Non-Small-Cell Lung | 29 |
| University of California Irvine Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 22 |
| University of California, Irvine | Myasthenia Gravis, Parkinson Disease, Acute Myeloid Leukemia (AML) | 19 |
| Chao Family Comprehensive Cancer Center, University of California, Irvine | Hepatocellular Carcinoma, Myelofibrosis, Pancreatic Cancer | 16 |
| UC Irvine Medical Center | Advanced Breast Cancer, Advanced Gastric Cancer, Advanced Liver Cancers | 14 |
| UC Irvine Health | B-cell Malignancy, Cachexia, Cervical Cancer | 12 |
| Saint Joseph Hospital - Orange | Recurrent Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma | 11 |
| NRC Research Institute | Bipolar Disorder, Bipolar I Disorder, Autism Spectrum Disorder | 11 |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Neoplasm Metastasis, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung | 9 |
| Chao Family Comprehensive Cancer Center University of California, Irvine | Melanoma (Skin), Cervical Cancer, Chronic Myeloid Leukemia | 8 |
| University of California, Irvine Medical Center | Cancer, Lung, Cardiovascular Diseases, Colorectal Cancer; Lung Cancer | 8 |
| Knowledge Research Center | Ulcerative Colitis, Ankylosing Spondylitis, Autoimmune Diseases | 7 |
| ATP Clinical Research | Bipolar Disorder, Bipolar Depression, Bipolar I Disorder | 7 |
| Children's Hospital Orange County | ALL, AML, Acute Undifferentiated Leukemia | 6 |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Gastric Cancer, Triple Negative Breast Neoplasms, Acute Myeloid Leukemia | 6 |
| UCI Health | Heart Failure, Cancer, Crohn's Disease | 6 |
| Chao Family Comprehensive Cancer Center | Advanced Clear Cell Renal Cell Carcinoma, Chronic Lymphocytic Leukemia, Endometrial Cancer | 4 |
| Chao Family Comprehensive Cancer Center, University of California Irvine | Allogeneic Stem Cell Transplantation, Breast Cancer, Colorectal Cancer | 4 |
| Children's Hospital of Orange County (CHOC) | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Anti-myostatin | 4 |
| UCI Medical Center | Deep Venous Thrombosis, Locally Advanced Solid Tumor, Metastatic Solid Tumor | 4 |
| Children's Hospital of Orange County Main Campus - Orange | Acute Myeloid Leukemia, Idiopathic Short Stature, Noonan Syndrome | 3 |
| Clinical Trial Site | Cerebral Amyloid Angiopathy, GNE Myopathy, Generalized Myasthenia Gravis | 3 |
| Clinnova Research Solutions | Liver Fibrosis, Metabolic Dysfunction Associated Steatohepatitis, Metabolic Dysfunction Associated Steatohepatitis (MASH) | 3 |
Recruiting trials in Orange grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Hipa.ai aggregates every recruiting study in Orange from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 539 recruiting clinical trials in Orange, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Orange compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Orange include Breast Cancer (11), Hepatocellular Carcinoma (9), Acute Myeloid Leukemia (8), Colorectal Cancer (7), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orange on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Orange include Children's Hospital of Orange County, UC Irvine Health/Chao Family Comprehensive Cancer Center, University of California Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Orange are Cancer & tumors (221), Cardiovascular (22), Neurology & pain (20). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.