Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow

Part of paid clinical trials in Orange, California.

Sponsor
University of California, Irvine
Study ID
NCT07281781
Phase
PHASE1/PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Myelofibrosis
  • Myelofibrosis; Anemia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Nelfinavir — DRUG
    Taken twice daily

Study Details

This is a phase I/II protocol investigating whether Nelfinavir can improve anemia and lower serum fibrosis biomarkers in Myelofibrosis patients.

Key Dates

Start date
Sep 16, 2025
Status verified
Apr 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Nelfinavir
    Given Orally

Primary Outcome Measure

Change in Hepcidin Levels [ Time Frame: 30 days ]

Central Contacts

  • Chao Family Comprehensive Cancer Center University of California, Irvine
    1-877-827-8839
    [email protected]
  • University of California Irvine Medical

Locations (1)

FacilityCityStateZIPSite coordinators
Chao Family Comprehensive Cancer Center, University of California, IrvineOrangeCalifornia92868
Angela Fleischman, MD, PhD
[email protected]
877-827-8839

Find similar trials in Orange, CA

By research site
Chao Family Comprehensive Cancer Center, University of California, Irvine· Orange, CA

Related Studies