Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

Part of paid clinical trials in Irvine, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT07100080
Phase
PHASE2/PHASE3
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Iza-bren — DRUG
    Specified dose on specified days
  • Carboplatin — DRUG
    Specified dose on specified days
  • Cisplatin — DRUG
    Specified dose on specified days
  • Pemetrexed — DRUG
    Specified dose on specified days

Study Details

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Key Dates

Start date
Nov 5, 2025
Status verified
May 2026
Primary completion
Dec 15, 2028
Completion
Nov 15, 2030

Study Design

Enrollment
500 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
  • Experimental: Arm B
  • Active Comparator: Arm C
  • Experimental: Arm D
  • Active Comparator: Arm E

Primary Outcome Measure

Recommended Phase 3 Dose (RP3D) of BMS-986507 [ Time Frame: Approximately 3 months after the first dose ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (28)

FacilityCityStateZIPSite coordinators
Local Institution - 0279IrvineCalifornia92612
Site 0279
Local Institution - 0154OrangeCalifornia92868-3201
Site 0154
Shaw Cancer CenterEdwardsColorado81632
Erin Schwab, Site 0139
970-569-7608
Local Institution - 0085GainesvilleFlorida32610-
Local Institution - 0142Pembroke PinesFlorida33028
Site 0142
Piedmont HealthcareAtlantaGeorgia30318
Andrew Pippas, Site 0270
706-660-6449
John B Amos Cancer CenterColumbusGeorgia31904
Andrew Pippas, Site 0143
706-660-6449
Rush University Medical CenterChicagoIllinois60607
Helen Ross, Site 0153
312-942-5904
Dana-Farber Cancer InstituteBostonMassachusetts02215
Julia Rotow, Site 0067
617-632-6049
Washington University School of MedicineSt LouisMissouri63108
Ece Cali Daylan, Site 0091
314-273-8008
Renown Regional Medical CenterRenoNevada89502
Katharine Thomas, Site 0276
775-985-4000
Perlmutter Cancer Center at NYU Langone Hospital - Long IslandMineolaNew York11501
Rajwanth Veluswamy, Site 0269
212-731-5662
NYU Langone HealthNew YorkNew York10016
Rajwanth Veluswamy, Site 0090
212-731-5662
Weill Cornell Medical CollegeNew YorkNew York10065
Ashish Saxena, Site 0158
631-745-0359
Rochester General Hospital Infectious DiseaseRochesterNew York14621
MEHUL PATEL, Site 0186
585-922-4020
University Hospitals Cleveland Medical CenterClevelandOhio44106
Matthew Mirsky, Site 0087
301-980-8969
Local Institution - 0284ColumbusOhio43210
Site 0284
Local Institution - 0171PortlandOregon97239
Site 0171
Providence Cancer Institute Franz ClinicPortlandOregon97213
Rachel Sanborn, Site 0038
503-215-5696
Providence St. Vincent Medical CenterPortlandOregon97225
Rachel Sanborn, Site 0275
503-215-5696
Hospital of the University of PennsylvaniaPhiladelphiaPennsylvania19104
Melina Marmarelis, Site 0205
267-438-8154
West Penn Allegheny HealthPittsburghPennsylvania15224
Ariel Lopez Chavez, Site 0088
503-494-8426
Local Institution - 0268ChattanoogaTennessee37404-
Tennessee OncologyNashvilleTennessee37203
Wade Iams, Site 0093
615-322-4967
Local Institution - 0025HoustonTexas77030
Site 0025
Local Institution - 0173San AntonioTexas78229
Site 0173
University of Virginia Health SystemCharlottesvilleVirginia22908
Ryan Gentzler, Site 0145
434-924-4251
Virginia Commonwealth University (Vcu)RichmondVirginia23219
Renato Martins, Site 0138
804-828-7999

Find similar trials in Irvine, CA

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Local Institution - 0279· Irvine, CALocal Institution - 0154· Orange, CAShaw Cancer Center· Edwards, COLocal Institution - 0085· Gainesville, FLLocal Institution - 0142· Pembroke Pines, FLPiedmont Healthcare· Atlanta, GA

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