Heart disease Clinical Trials in New York, NY

As of June 2026, 123 paid clinical trials are recruiting for Heart disease in New York, New York. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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123 clinical trials for Heart disease

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

Apply to this trial

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart Failure

31 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 40 - 85

Code: NCT06122779·Phase 2·Recruiting

Apply to this trial

SELUTION 4 De Novo Small Vessel IDE Trial

for Coronary Artery Disease

43 locations incl. Jonesboro

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05946629·Recruiting

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CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

for Heart Failure

47 locations incl. Phoenix

Sponsor: Procyrion

Sex: All·Age: 21+

Code: NCT05677100·Recruiting

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The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

for Coronary Artery Disease

9 locations incl. Birmingham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05618353·Phase 4·Recruiting

Apply to this trial

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Physiology-guided vs Angiography-guided Non-culprit Lesion Complete Revascularization for Acute MI & Multivessel Disease

for Acute Myocardial Infarction

13 locations incl. Los Angeles

Sponsor: Population Health Research Institute

Sex: All·Age: 18+

Code: NCT05701358·Recruiting

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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

20 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting

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A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

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Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

for Adult Congenital Heart Disease

3 locations incl. Baltimore

Sponsor: Leiden University Medical Center

Sex: All·Age: 18+

Code: NCT06932081·Recruiting

Apply to this trial

His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

14 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting

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Continuation of the nuMoM2b Heart Health Study

for Cardiovascular Diseases

14 locations incl. Orange

Sponsor: RTI International

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05472597·Enrolling By Invitation

EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

Enhanced Nutritional Optimization in LVAD Trial

for Heart Failure

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT05655910·Recruiting

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Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health

for Sedentary Behavior

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05353322·Recruiting

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Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

for Heart Failure (for Example, Fluid Overload)

17 locations incl. Tucson

Sponsor: Nuwellis, Inc.

Sex: All·Age: 18+

Code: NCT05318105·Recruiting

Apply to this trial

The CONFORM Pivotal Trial

for Atrial Fibrillation

76 locations incl. Birmingham

Sponsor: Conformal Medical, Inc

Sex: All·Age: 18+

Code: NCT05147792·Recruiting

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

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TSCS for Acute SCI

for Acute Spinal Cord Injury

1 location in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18 - 89

Code: NCT05305118·Recruiting

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Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI

for Acute Spinal Cord Injury

1 location in New York

Sponsor: Jill M. Wecht, Ed.D.

Sex: All·Age: 14 - 100

Code: NCT06000592·Recruiting

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Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

55 locations incl. Huntsville

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Use of ReDS Technology in Patients With Acute Heart Failure

for Heart Failure

1 location in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04305717·Recruiting

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Heart Attack Research Program: Platelet Sub-Study (HARP)

for Myocardial Infarction

1 location in New York

Sponsor: NYU Langone Health

Sex: Female·Age: 21 - 99·Accepts healthy volunteers

Code: NCT03022552·Recruiting

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Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

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Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

for Congenital Heart Disease

5 locations incl. Gainesville

Sponsor: Columbia University

Sex: All·Age: All ages

Code: NCT03891160·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

Randomization of Single vs Multiple Arterial Grafts

for Coronary Artery Disease

11 locations incl. Boulder

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 70

Code: NCT03217006·Recruiting

Apply to this trial

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

Apply to this trial

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

38 locations incl. Alexander City

Sponsor: Uppsala University

Sex: All·Age: 50 - 99

Code: NCT02901184·Phase 3·Recruiting

Apply to this trial

CardioFocus HeartLight Post-Approval Study

for Atrial Fibrillation

4 locations incl. Tucson

Sponsor: CardioFocus

Sex: All·Age: 18+

Code: NCT03168659·Recruiting

Apply to this trial

Food and Microbiome Longitudinal Investigation (FAMiLI)

for Cancer

1 location in New York

Sponsor: NYU Langone Health

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT03293758·Recruiting

Apply to this trial

Conditions in Heart disease (New York, NY)

Heart failure· 44 Cardiovascular disease (general)· 29 Coronary artery disease· 21 Atrial fibrillation· 20 Hypertension (high blood pressure)· 19 Congenital heart disease· 6 Myocardial infarction (heart attack)· 3