Heart Attack Research Program: Platelet Sub-Study (HARP)

Part of paid clinical trials in New York, New York.

Sponsor
NYU Langone Health
Study ID
NCT03022552
Status
Recruiting
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Conditions

  • Myocardial Infarction

Eligibility Criteria

Sex
FEMALE
Age
21 Years - 99 Years
Healthy Volunteers
Accepted

Study Details

This prospective observational cohort study, will investigate the platelet phenotype, platelet genetic composition, and role of platelets as effector cells in women and men with myocardial infarction (MINOCA or MI-CAD) and controls. This study, which will take place at NYU and Bellevue Medical Center, and participating external sites. May have concurrent enrollment with the HARP Main Imaging (NCT02914483). Additionally, a sex, group of age and race matched disease controls 'CATH-NOCA' composed of women and men with stable angina referred for cardiac catheterization, will be enrolled. Blood obtained during the initial catheterization and 2 months post-MI will be utilized for platelet testing.

Key Dates

Start date
Jul 1, 2020
Status verified
Apr 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
350 participants (estimated)

Arms

  • Arm: MINOCA
    Women with myocardial infarction (MI) with demonstrated non-obstructive coronary artery disease during cardiac catheterization (less than 50% blockage in any major vessel).
  • Arm: MI-CAD
    Women with myocardial infarction (MI) with demonstrated obstructive coronary artery disease during cardiac catheterization (50% or greater blockage in any major vessel) or previous history of percutaneous coronary intervention (PCI) or or coronary artery bypass graft (CABG).
  • Arm: CATH-NOCA
    Women with stable angina that are age and race matched to women in the MINOCA arm that are clinically referred for cardiac catheterization

Primary Outcome Measure

Examination of Platelet Activity Markers [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NYU Langone Medical CenterNew YorkNew York10016
Jeffrey Berger, MD

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By research site
NYU Langone Medical Center· New York, NY

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