Ultrafiltration Versus IV Diuretics in Worsening Heart Failure

Part of paid clinical trials in Tucson, Arizona.

Sponsor
Nuwellis, Inc.
Study ID
NCT05318105
Status
Recruiting
Apply to this trial

Conditions

  • Fluid Overload
  • Heart Failure
  • Heart Failure (for Example, Fluid Overload)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Aquadex Smartflow® System — DEVICE
    ultrafiltration
  • IV Loop Diuretics — DRUG
    diuretics

Study Details

The REVERSE-HF study is a randomized controlled trial to evaluate clinical outcomes of adjustable ultrafiltration with the Aquadex System as compared to adjustable IV loop diuretics in patients with worsening heart failure (HF) and fluid overload.

Key Dates

Start date
Jun 28, 2022
Status verified
May 2025
Primary completion
Sep 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
372 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Aquadex ultrafiltration therapy
  • Active Comparator: IV loop diuretics

Primary Outcome Measure

Time to first heart failure (HF) event [ Time Frame: within 30 days ]

Central Contacts

Locations (17)

FacilityCityStateZIPSite coordinators
Banner HealthTucsonArizona85721
Dalise Dai
[email protected]
312-237-5891
Radha Gopalan, MD (PRINCIPAL_INVESTIGATOR)
MemorialCare, Long Beach Medical CenterLong BeachCalifornia90806
Morgan Ebbert
[email protected]
Andrew Yoon, MD (PRINCIPAL_INVESTIGATOR)
Sharp Memorial Hospital, San Diego Cardiac CenterSan DiegoCalifornia92123
Emma Burkhalter, RN, MSN
[email protected]
858-244-6889
Diana Nguyen
[email protected]
Brian Jaski, MD (PRINCIPAL_INVESTIGATOR)
University of California San FranciscoSan FranciscoCalifornia94143-
BayCare Medical Group, Morton PlantClearwaterFlorida33756-
St. Joseph's HospitalTampaFlorida33614-
University of KentuckyLexingtonKentucky40536
Jennifer Isaacs
[email protected]
859-323-4738
Andrew Kolodziej, MD (PRINCIPAL_INVESTIGATOR)
Henry Ford HealthDetroitMichigan48202
Kelsey Neaton
[email protected]
Jennifer Cowger, MD (PRINCIPAL_INVESTIGATOR)
Mount Sinai MorningsideNew YorkNew York10025
Katharine Idrissi
[email protected]
Ashish Correa, MBBS (PRINCIPAL_INVESTIGATOR)
Northwell HealthNew YorkNew York10075
Alana Gulliver
[email protected]
212-434-3802
Sirish Vullaganti, MD (PRINCIPAL_INVESTIGATOR)
The Mount Sinai HospitalNew YorkNew York10029
Kathryn Bass
[email protected]
212-241-3149
Umesh Gidwani, MD (PRINCIPAL_INVESTIGATOR)
The Christ HospitalCincinnatiOhio45219
Karen Federle
[email protected]
Sitaramesh Emani, MD (PRINCIPAL_INVESTIGATOR)
The Ohio State UniversityColumbusOhio43215
maeve McLoughlin, MPH
[email protected]
614-292-4084
Sitaramesh Emani, MD (PRINCIPAL_INVESTIGATOR)
Abington Jefferson HealthAbingtonPennsylvania19001
Colleen Marchand, RN
[email protected]
215-481-4661
Donald Haas, MD (PRINCIPAL_INVESTIGATOR)
Jackson Madison County General HospitalJacksonTennessee38301
Mary Harris, RN
[email protected]
731-541-6910
Shree Mulay, MD (PRINCIPAL_INVESTIGATOR)
Baylor Scott & White Research InstituteDallasTexas75207
Amy Watts
[email protected]
254-724-1392
Jamie Hernandez Montfort, MD (PRINCIPAL_INVESTIGATOR)
Sentara Norfolk General Heart HospitalNorfolkVirginia23507
Kelly Jordan
[email protected]
Ashley Williams
[email protected]
Amin Yehya, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Tucson, AZ

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Banner Health· Tucson, AZMemorialCare, Long Beach Medical Center· Long Beach, CASharp Memorial Hospital, San Diego Cardiac Center· San Diego, CAUniversity of California San Francisco· San Francisco, CABayCare Medical Group, Morton Plant· Clearwater, FLSt. Joseph's Hospital· Tampa, FL

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