Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

for Lymphoma, Non-Hodgkin

174 locations incl. Birmingham

Sponsor: American Society of Clinical Oncology

Sex: All·Age: 12+

Code: NCT02693535·Phase 2·Recruiting

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Conjoint Analysis of Patient Preferences in Joint Interventions

for Arthritis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 85

Code: NCT02664337·Enrolling By Invitation

Muscle Fiber Fragment Treatment for Urinary Incontinence

for Urinary Incontinence

1 location in Winston-Salem

Sponsor: Wake Forest University

Sex: Female·Age: 18 - 75

Code: NCT01953263·Phase 1, Phase 2·Recruiting

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GBE Deficiency (GSD IV and APBD) Natural History Study

for Glycogen Storage Disease Type IV

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT02683512·Recruiting

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Investigating the Impact of Obesity on Pubertal Development in Girls

for Obesity

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: Female·Age: 8 - 14·Accepts healthy volunteers

Code: NCT02583646·Recruiting

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

245 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting

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CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

44 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting

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Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

52 locations incl. Phoenix

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting

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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

for Neuroblastoma

24 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: Up to 22

Code: NCT02559778·Phase 2·Recruiting

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Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

780 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

33 locations incl. Birmingham

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting

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NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

for Asthma

1 location in Research Triangle Park

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 18 - 60

Code: NCT02327897·Recruiting

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Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry

for Rheumatic Joint Disease

75 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: Up to 21

Code: NCT02418442·Recruiting

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JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

for Non-Small Cell Lung Cancer

40 locations incl. La Jolla

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT02468024·Phase 3·Recruiting

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Total Shoulder Arthroplasty Multi-Center Registry

for Shoulder Arthroplasty

22 locations incl. Phoenix

Sponsor: Arthrex, Inc.

Sex: All·Age: 18 - 100

Code: NCT03511586·Recruiting

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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

for Eosinophilic Gastrointestinal Disorders (EGIDs)

19 locations incl. Phoenix

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 3+

Code: NCT02523118·Recruiting

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Clinical Outcomes Study of the Nexel Total Elbow

for Elbow Joint Destruction

4 locations incl. Golden

Sponsor: Zimmer Biomet

Sex: All·Age: 18+

Code: NCT02469662·Recruiting

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Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

for Metastatic Breast Cancer

3 locations incl. Baltimore

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT02422641·Phase 2·Recruiting

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Collection and Storage of Tissue and Blood Samples From Patients With Cancer

for Hematopoietic and Lymphatic System Neoplasm

140 locations incl. Birmingham

Sponsor: National Cancer Institute LAO

Sex: All·Age: 2 Months+

Code: NCT02474160·Recruiting

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Use of an Integrated Orthotic and Rehabilitation Initiative for Treatment of Lower Extremity Musculoskeletal Disorders

for Musculoskeletal Injury

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05780502·Recruiting

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Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in Children

for Focal Segmental Glomerulosclerosis

12 locations incl. Loma Linda

Sponsor: Kaneka Medical America LLC

Sex: All·Age: Up to 21

Code: NCT02235857·Recruiting

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C-Brace Prospective Registry

for Pareses

70 locations incl. Harrison

Sponsor: Otto Bock Healthcare Products GmbH

Sex: All·Age: All ages

Code: NCT04640584·Recruiting

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University of North Carolina (UNC) Barrett's Esophagus and Esophageal Cancer Biorepository

for Barrett's Esophagus

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT02427269·Enrolling By Invitation

Simple Bone Cysts in Kids

for Bone Cyst

11 locations incl. Birmingham

Sponsor: The Hospital for Sick Children

Sex: All·Age: 2 - 21

Code: NCT02193841·Phase 3·Recruiting

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Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy

for Immunosuppression

1 location in Durham

Sponsor: Linda Cendales

Sex: All·Age: 18 - 65

Code: NCT02310867·Phase 2·Recruiting

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Biomarker Development for Muscular Dystrophies

for Myotonic Dystrophy

5 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT05019625·Recruiting

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Registry of Patients With Hypophosphatasia

for Hypophosphatasia (HPP)

20 locations incl. Centennial

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: All ages

Code: NCT02306720·Enrolling By Invitation

Natural History Study of Patients With Hypophosphatasia (HPP)

for Hypophosphatasia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT02237625·Recruiting

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UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

for Adrenoleukodystrophy

1 location in Durham

Sponsor: Joanne Kurtzberg, MD

Sex: All·Age: 1 Week - 22

Code: NCT02254863·Phase 1·Recruiting

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SC2i Tissue and Data Repository Protocol

for Critical Illness

4 locations incl. Atlanta

Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02182180·Recruiting

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Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

44 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting

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Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

for Alzheimer Disease

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT03089827·Enrolling By Invitation

Sickle Cell Clinical Research and Intervention Program

for Sickle Cell Disease

6 locations incl. Peoria

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT02098863·Recruiting

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Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

for Hodgkin Lymphoma in Remission

69 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT01790152·Recruiting

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Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

for Parkinson's Disease

28 locations incl. Aliso Viejo

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT02071134·Recruiting

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Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

for Relapsed or Refractory Acute Myeloid Leukemia (AML)

26 locations incl. Birmingham

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT02074839·Phase 1·Recruiting

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Wake Forest Alzheimer's Disease Clinical Core

for Alzheimer's Disease

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT03140865·Recruiting

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Observational Pharmaco-Epidemiology Research & Analysis

for Chronic Disease

1 location in Durham

Sponsor: Epividian

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT03813862·Recruiting

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Integrated Cancer Repository for Cancer Research

for Pancreatic Cancer

42 locations incl. Greenwood Village

Sponsor: University of Nebraska

Sex: All·Age: 19 - 110·Accepts healthy volunteers

Code: NCT02012699·Recruiting

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A Long-term Extension Study of PCI-32765 (Ibrutinib)

for Chronic Lymphocytic Leukemia

Drug: Ibrutinib

32 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT01804686·Phase 3·Recruiting

Apply to this trial