Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

for HER2-negative Breast Cancer

7 locations incl. Chicago

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 99

Code: NCT05029999·Phase 1·Recruiting

Apply to this trial

Examining the Effects of Estradiol on Neural and Molecular Response to Reward

for Depression

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 45 - 55

Code: NCT05282277·Phase 4·Recruiting

Apply to this trial

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

164 locations incl. Birmingham

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting

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Use of CereGate Therapy for Freezing of Gait in PD

for Parkinson Disease

7 locations incl. Redwood City

Sponsor: CereGate Inc.

Sex: All·Age: 21 - 80

Code: NCT05292794·Recruiting

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(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

for Advanced Gastrointestinal Stromal Tumors

36 locations incl. Birmingham

Sponsor: Cogent Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05208047·Phase 3·Recruiting

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A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

18 locations incl. Duarte

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05131022·Phase 1·Recruiting

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Ethicon Pelvic Mesh Post Market Clinical Follow-up Registry

for Stress Urinary Incontinence

4 locations incl. New Haven

Sponsor: Ethicon, Inc.

Sex: Female·Age: 21+

Code: NCT04829175·Recruiting

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Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

for Non-Muscle Invasive Bladder Neoplasms

25 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05316155·Phase 1, Phase 2·Recruiting

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Effect of Ketamine and Etomidate During RSI on Long Term Outcomes

for Post-Traumatic Stress Disorder

6 locations incl. Birmingham

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06179485·Enrolling By Invitation

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

for Advanced Solid Tumor

11 locations incl. Miami

Sponsor: Aulos Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05267626·Phase 1, Phase 2·Recruiting

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Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With Diabetic Retinopathy

for Diabetic Retinopathy, DR

19 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: All ages

Code: NCT05296447·Enrolling By Invitation

Appalachian Partnership to Reduce Disparities (Aim 2)

for HIV/AIDS

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04378439·Recruiting

Apply to this trial

Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program

for Cigarette Smoking-Related Carcinoma

222 locations incl. Kingman

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05008848·Phase 3·Recruiting

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

219 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting

Apply to this trial

The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

35 locations incl. Birmingham

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting

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Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

for Proteinuric Kidney Disease

227 locations incl. Alabaster

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 10 - 65

Code: NCT05312879·Phase 2, Phase 3·Recruiting

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4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

20 locations incl. Birmingham

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting

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Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

15 locations incl. La Jolla

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT04895436·Phase 2·Recruiting

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A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non Small Cell Lung Cancer

Drug: Telisotuzumab Vedotin

50 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT04928846·Phase 3·Recruiting

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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer

for Cervical Cancer

134 locations incl. Goodyear

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT04831580·Recruiting

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Comparative Performance of a Vaginal Yeast Test

for Vulvovaginal Candidiasis

2 locations incl. Fort Bragg

Sponsor: Uniformed Services University of the Health Sciences

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05079711·Recruiting

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Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

for Schizophrenia

7 locations incl. Los Angeles

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 65

Code: NCT05208190·Phase 4·Recruiting

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Long-Term Follow-up Study

for Lymphoma, Non-Hodgkin

31 locations incl. Birmingham

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05332054·Enrolling By Invitation

Global Utilization And Registry Database for Improved preservAtion of doNor Livers

for Liver Diseases

7 locations incl. Birmingham

Sponsor: Paragonix Technologies

Sex: All·Age: 18+

Code: NCT05082077·Enrolling By Invitation

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

for B-cell Acute Lymphoblastic Leukemia

20 locations incl. Los Angeles

Sponsor: Etan Orgel

Sex: All·Age: 10 - 25

Code: NCT05082519·Phase 2·Recruiting

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A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

for Relapsed/Refractory Follicular Lymphoma

Drug: Rituximab

49 locations incl. Fresno

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT05100862·Phase 3·Recruiting

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

17 locations incl. Duarte

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting

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Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases

for Breast Cancer

Drug: Durvalumab

7 locations incl. Birmingham

Sponsor: Colette Shen

Sex: All·Age: 18+

Code: NCT04711824·Phase 1, Phase 2·Recruiting

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A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

for Multiple Myeloma

28 locations incl. Phoenix

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05201781·Phase 4·Recruiting

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EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

for COVID-19

50 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 0 - 17

Code: NCT05261139·Phase 3·Recruiting

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An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia

for Schizophrenia

Drug: KarXT

79 locations incl. Phoenix

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 18 - 65

Code: NCT05304767·Phase 3·Recruiting

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Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

5 locations incl. Minneapolis

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting

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A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

for Leukemia, Myeloid, Acute

33 locations incl. Newport Beach

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 12+

Code: NCT04988555·Phase 1, Phase 2·Recruiting

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Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

for Migraine

Drug: Rimegepant

54 locations incl. Fort Smith

Sponsor: Pfizer

Sex: All·Age: 6 - 17

Code: NCT05156398·Phase 3·Recruiting

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Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

15 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting

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Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)

for Invasive Fungal Infection

5 locations incl. San Diego

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Day - 2

Code: NCT04665037·Phase 2·Recruiting

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Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM

for Epiretinal Membrane

46 locations incl. Scottsdale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 50+

Code: NCT05145491·Recruiting

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Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

for Mitral Valve Regurgitation

24 locations incl. Los Angeles

Sponsor: Annetine Gelijns

Sex: All·Age: 60+

Code: NCT05051033·Recruiting

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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

5 locations incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05145400·Phase 2·Recruiting

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A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

for Non-Small Cell Lung Cancer

Drug: Durvalumab

43 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05211895·Phase 3·Recruiting

Apply to this trial