Paid Clinical Trials in North Carolina

North Carolina has 2,943 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)

for Avascular Necrosis of the Talus

1 location in Charlotte

Sponsor: Restor3D

Sex: All·Age: 22+

Code: NCT06311331·Enrolling By Invitation

Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

for Obstetrical Complications

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06605118·Phase 3·Recruiting

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Streamlined Resin Y90 Radiation Segmentectomy for Small HCC

for Hepatocellular Carcinoma (HCC)

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06618300·Enrolling By Invitation

MED-EL Remote Care Multi-Center Feasibility Study

for Hearing Loss, Sensorineural

3 locations incl. Iowa City

Sponsor: Med-El Corporation

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05973669·Enrolling By Invitation

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

for Breast Reconstruction

22 locations incl. Los Angeles

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06575192·Phase 3·Recruiting

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Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest

for Lung Inflammation

1 location in Chapel Hill

Sponsor: Environmental Protection Agency (EPA)

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06943989·Enrolling By Invitation

PULSED AF Post-Approval Study

for Atrial Fibrillation

18 locations incl. Tampa

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT06578104·Recruiting

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Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program

for Glycogen Storage Disease Type Ia

9 locations incl. Orange

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: 2+

Code: NCT06636383·Recruiting

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Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

for Hemorrhagic Shock

23 locations incl. Tucson

Sponsor: Philip Spinella

Sex: All·Age: Up to 17

Code: NCT06070350·Phase 3·Recruiting

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A Multi-center, Early Feasibility Study of Using the Mechanical Tissue Resuscitation™ (MTR®) Therapy System for Removal of Excess Fluid in Subjects Who Have Had a Portion of Their Skull Removed to Expose the Dura/Brain and Require Drainage for Fluid Removal.

for Clinical Need for Craniotomy or Craniectomy

3 locations incl. Buffalo

Sponsor: Renovo Concepts, Inc.

Sex: All·Age: 22 - 65

Code: NCT06201429·Recruiting

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

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POMEGRANATE Trial: Comparing Reia Pessary Versus Standard of Care Pessary for Pelvic Organ Prolapse Treatment

for Pelvic Organ Prolapse

9 locations incl. Birmingham

Sponsor: Medstar Health Research Institute

Sex: Female·Age: 18+

Code: NCT06634459·Recruiting

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Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking

for Stroke

2 locations incl. Durham

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 70

Code: NCT07050355·Recruiting

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Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

for Anterior Cruciate Ligament Injuries

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 14 - 35

Code: NCT05949177·Recruiting

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

Drug: Cemdisiran

153 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting

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The THOR IDE Study

for Peripheral Artery Disease

29 locations incl. St. Helena

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT05916950·Recruiting

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Lemborexant Treatment of Insomnia Linked to Epilepsy

for Epilepsy

1 location in Durham

Sponsor: University of Manitoba

Sex: All·Age: 18+

Code: NCT06262594·Phase 3·Recruiting

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The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

for Metastatic Breast Cancer

73 locations incl. Chandler

Sponsor: American Society of Clinical Oncology

Sex: All·Age: 65+

Code: NCT06377852·Phase 3·Recruiting

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TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for Breast Cancer

11 locations incl. Birmingham

Sponsor: Ana C Garrido-Castro, MD

Sex: All·Age: 18+

Code: NCT06533826·Phase 2·Recruiting

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A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)

for Alzheimer Disease

Drug: LY4006895

11 locations incl. Los Alamitos

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 85·Accepts healthy volunteers

Code: NCT06657768·Phase 1·Recruiting

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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

for Cardiovascular Diseases

37 locations incl. Little Rock

Sponsor: BrioHealth Solutions, Inc.

Sex: All·Age: 18 - 100

Code: NCT06310031·Recruiting

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Eating Disorders Genetics Initiative 2

for Anorexia Nervosa

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 12 - 99·Accepts healthy volunteers

Code: NCT06594913·Recruiting

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ATHNdataset Registry

for Hemophilia

1 location in Hickory

Sponsor: American Thrombosis and Hemostasis Network

Sex: All·Age: All ages

Code: NCT06820515·Recruiting

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A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

for Sickle Cell Disease

14 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06439082·Phase 3·Recruiting

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Emovi 3D Knee Assessment Device Intervention for Operational Readiness

for Patellofemoral Pain

2 locations incl. Honolulu

Sponsor: Womack Army Medical Center

Sex: All·Age: 18 - 50

Code: NCT06517056·Recruiting

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Hypertonic Saline in NCFB

for Bronchiectasis

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT06242795·Phase 4·Recruiting

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Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

for Classic Follicular Lymphoma

Drug: Mosunetuzumab

267 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06337318·Phase 3·Recruiting

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A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

for Primary Myelofibrosis

13 locations incl. Palo Alto

Sponsor: Ajax Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06343805·Phase 1·Recruiting

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GERD in Children With Cystic Fibrosis

for GERD in Children

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 2 - 18

Code: NCT06617013·Recruiting

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Study to Evaluate Avacopan in Combination With a Rituximab or Cyclophosphamide-containing Regimen, in Children From 6 Years to < 18 Years of Age With AAV.

for Vasculitis

Drug: Rituximab

10 locations incl. Atlanta

Sponsor: Amgen

Sex: All·Age: 6 - 17

Code: NCT06321601·Phase 3·Recruiting

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

92 locations incl. Mobile

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting

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Sacral Neuromodulation for Male Overactive Bladder (MOAB)

for Overactive Bladder

20 locations incl. Birmingham

Sponsor: Axonics, Inc.

Sex: Male·Age: 18+

Code: NCT06511141·Recruiting

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

58 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting

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A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

for Metastatic Castration-Resistant Prostate Cancer

Drug: Mevrometostat

44 locations incl. Chandler

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT06629779·Phase 3·Recruiting

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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia

for Agitation Associated With Alzheimer's Dementia

30 locations incl. Anaheim

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 55+

Code: NCT06651567·Phase 2·Recruiting

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A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature

for Idiopathic Short Stature

Drug: Vosoritide

35 locations incl. California City

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 3 - 11

Code: NCT06382155·Phase 2·Recruiting

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Novel Digital Application for Patients With Acute Leukemia

for Relapsed Adult Acute Myeloid Leukemia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120

Code: NCT06472128·Recruiting

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Open-Label Extension Study of Setmelanotide

for Obesity Associated With Defects in Leptin-melanocortin Pathway

13 locations incl. Scottsdale

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 2+

Code: NCT06596135·Phase 3·Enrolling By Invitation

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

Drug: Intismeran autogene

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting

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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

for Hypertensive Disorders of Pregnancy

16 locations incl. Birmingham

Sponsor: Ohio State University

Sex: Female·Age: 14 - 35

Code: NCT06468202·Phase 4·Recruiting

Apply to this trial