Eating Disorders Genetics Initiative 2

Part of paid clinical trials in Chapel Hill, North Carolina.

Sponsor
University of North Carolina, Chapel Hill
Study ID
NCT06594913
Status
Recruiting
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Conditions

  • Anorexia Nervosa
  • Avoidant Restrictive Food Intake Disorder
  • Binge-Eating Disorder
  • Bulimia Nervosa

Eligibility Criteria

Sex
ALL
Age
12 Years - 99 Years
Healthy Volunteers
Accepted

Interventions

  • Eating disorder diagnosis group — OTHER
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.

Study Details

The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

Key Dates

Start date
Oct 28, 2024
Status verified
May 2025
Primary completion
Aug 1, 2027
Completion
Aug 1, 2027

Study Design

Enrollment
20,000 participants (estimated)

Arms

  • Arm: Anorexia nervosa
    Individuals with a self-reported lifetime history of anorexia nervosa.
  • Arm: Bulimia nervosa
    Individuals with a self-reported lifetime history of bulimia nervosa.
  • Arm: Binge-eating disorder
    Individuals with a self-reported lifetime history of binge-eating disorder.
  • Arm: ARFID
    Individuals with a self-reported lifetime history of avoidant restrictive food intake disorder.
  • Arm: Control
    Individuals with no history of disordered eating behaviors or symptoms

Primary Outcome Measure

Number of Participants Identified with an Eating Disorder Diagnosis by Category [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of North Carolina at Chapel HillChapel HillNorth Carolina27599-7160
Laura M Thornton, PhD
[email protected]
804-690-3079

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