Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

for PDAC

18 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06922591·Phase 1, Phase 2·Recruiting

Apply to this trial

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplant

for Hematopoietic Stem Cell Transplantation

3 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 80

Code: NCT06953648·Not Yet Recruiting

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

for B Acute Lymphoblastic Leukemia

137 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 366 Days - 46

Code: NCT06124157·Phase 2·Recruiting

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Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for B-cell Acute Lymphoblastic Leukemia

9 locations incl. Duarte

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 13 - 90

Code: NCT06533579·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

for Somatostatin Receptor Positive (SSTR+)

19 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 100

Code: NCT06784752·Phase 3·Recruiting

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Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

for Aortoiliac Occlusive Disease

19 locations incl. Fresno

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 100

Code: NCT06872905·Recruiting

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A Study to Evaluate ARV-806 in Adults With Advanced Cancer That Has the KRAS G12D Mutation

for KRAS G12D Mutation

14 locations incl. Phoenix

Sponsor: Arvinas Inc.

Sex: All·Age: 18+

Code: NCT07023731·Phase 1, Phase 2·Recruiting

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A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain

for Obesity

Drug: Retatrutide

25 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07035093·Phase 3·Recruiting

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Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

for Prostate Cancer (Adenocarcinoma)

350 locations incl. Anchorage

Sponsor: Canadian Cancer Trials Group

Sex: Male·Age: 18+

Code: NCT06592924·Phase 3·Recruiting

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Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition

for ADHD - Attention Deficit Disorder With Hyperactivity

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 6 - 9

Code: NCT06971640·Recruiting

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Implementation of an Oral Chemotherapy Adherence Intervention

for Solid Tumor

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 21+

Code: NCT06989489·Recruiting

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Evaluating the Safety and Tolerability of Orally Administered DF-003 in ROSAH Syndrome Patients

for ROSAH

3 locations incl. Bethesda

Sponsor: Shanghai Yao Yuan Biotechnology Ltd. (also known as Drug Farm)

Sex: All·Age: 18 - 65

Code: NCT06395285·Phase 1·Recruiting

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Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

for Ankle Sprains

2 locations incl. Lexington

Sponsor: University of Kentucky

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06868316·Recruiting

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A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

for Ulcerative Colitis

25 locations incl. Canoga Park

Sponsor: Spyre Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07012395·Phase 2·Recruiting

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Study to Assess the Efficacy and Safety of IMVT-1402 in Participants With Mild to Severe Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: IMVT-1402

46 locations incl. Huntsville

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 80

Code: NCT07039916·Phase 3·Recruiting

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Small Cell Lung Cancer Community Engagement to Eliminate Research Discepancies

for Small-cell Lung Cancer

52 locations incl. Multiple Locations

Sponsor: Addario Lung Cancer Medical Institute

Sex: All·Age: 18+

Code: NCT06486428·Recruiting

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Oral Ketorolac for IUD Pain Reduction

for IUD Insertion Pain

1 location in Hillsborough

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06853327·Phase 2·Enrolling By Invitation

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

386 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting

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A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

Drug: ALKS 2680

32 locations incl. Cullman

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT06843590·Phase 2·Recruiting

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Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)

for Muscular Dystrophy, Facioscapulohumeral

6 locations incl. Palo Alto

Sponsor: University of Kansas Medical Center

Sex: All·Age: 5 - 17

Code: NCT06847282·Recruiting

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A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

for Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer

Drug: zolbetuximab

36 locations incl. Birmingham

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT06901531·Phase 3·Recruiting

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A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Nephropathy (PMN)

for Primary Membranous Nephropathy

15 locations incl. Huntsville

Sponsor: Biogen

Sex: All·Age: 18 - 80

Code: NCT06962800·Phase 3·Recruiting

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Clinical Study of a Vaginal Cooling Device for the Treatment of Vulvovaginal Candidiasis (VVC)

for Vulvovaginal Candidiasis (VVC)

10 locations incl. Jacksonville

Sponsor: Coologics, Inc

Sex: Female·Age: 22 - 49

Code: NCT06983041·Recruiting

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for Endometrial Cancer

44 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06952504·Phase 3·Recruiting

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Automated Robotic TCD in Traumatic Brain Injury

for Brain Injuries, Traumatic

3 locations incl. Davis

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT05848297·Recruiting

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MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

for Coronary Artery Disease

24 locations incl. Gilbert

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 80

Code: NCT06271590·Recruiting

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Clinical Study of ARD103 CAR-T Therapy for Patients With R/R AML or MDS

for Acute Myeloid Leukemia, in Relapse

3 locations incl. Charlotte

Sponsor: ARCE Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06680752·Phase 1, Phase 2·Recruiting

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A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

for Chronic Lymphocytic Leukemia

20 locations incl. Jacksonville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876649·Phase 4·Recruiting

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A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia

18 locations incl. Miami

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876662·Phase 4·Recruiting

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A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

for Heart Failure

Drug: Empagliflozin

105 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06935370·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

for Asthma

Drug: PF-07275315

36 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT06977581·Phase 2·Recruiting

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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

for Delayed Graft Function

32 locations incl. Phoenix

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06830798·Phase 3·Recruiting

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Pelacarsen Roll-over Extension Program

for Atherosclerotic Cardiovascular Disease

Drug: Pelacarsen

91 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06875973·Phase 3·Recruiting

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Network to Understand Reproductive Rheumatology Registry

for Rheumatic Diseases

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 12 - 55

Code: NCT06940869·Enrolling By Invitation

A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

for Stress Urinary Incontinence (SUI)

13 locations incl. Los Angeles

Sponsor: UroMems SAS

Sex: Male·Age: 22+

Code: NCT06968741·Recruiting

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Keep Social Study for Young Adults

for Social Isolation

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 29·Accepts healthy volunteers

Code: NCT07005817·Enrolling By Invitation

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

for Lower Extremity Acute Limb Ischemia

31 locations incl. Scottsdale

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT06747117·Recruiting

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Va Meh Du: A Sports-based Mental Health Promotion Intervention for Karenni Refugees

for Coping Skills

1 location in Winston-Salem

Sponsor: University of North Carolina, Greensboro

Sex: Male·Age: 8+·Accepts healthy volunteers

Code: NCT06921499·Recruiting

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Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

129 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06672146·Phase 2·Recruiting

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A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine

for Acute Treatment of Migraine

13 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 6 - 11

Code: NCT06995729·Phase 1·Recruiting

Apply to this trial