Oral Ketorolac for IUD Pain Reduction

Conditions

• IUD Insertion Pain

Eligibility Criteria

Sex

FEMALE

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Ketorolac — DRUG
  The experimental condition to be examined by this study is the timing of administration of ketorolac prior to IUD insertion. Ketorolac 20mg PO has proven beneficial at certain timepoints during IUD insertion in prior studies, but pharmacokinetics indicate that it could require more time until peak analgesia.
• Placebo — DRUG
  Placebo will be used to control the timing of administration and be used to compare ketorolac to baseline standard pain control regimens

Study Details

To determine if oral ketorolac given at different timepoints prior to intrauterine device (IUD) insertion influences pain experienced during this procedure.

Key Dates

Start date

May 23, 2025

Status verified

May 2025

Primary completion

Jun 30, 2026

Completion

Jun 30, 2026

Study Design

Enrollment

108 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: K2 - Ketorolac 2-hour
  Receives Ketorolac 20mg PO at 2 hours prior and placebo at 1 hour prior to IUD
• Active Comparator: K1 - Ketorolac 1-hour
  Receives placebo at 2 hours and Ketorolac 20mg PO at 1 hour prior to IUD
• Placebo Comparator: K0 - Placebo control
  Receives placebo at 2 hours and at 1 hour prior to IUD

Primary Outcome Measure

Difference in mean VAS pain scores between study arms at 7 timepoints during and after IUD insertion [ Time Frame: All VAS pain scores will be measured during their IUD appointment. 5 timepoints will be measured during IUD insertion (~10 total minutes), 1 immediately after the procedure, 1 ten minutes afterwards ]

Locations (1)

Find similar trials in Hillsborough, NC

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• Development of a Pain Control Options Menu for IUD Insertion
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