Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

for Alzheimers Disease

68 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 90

Code: NCT07177352·Phase 3·Recruiting

Apply to this trial

Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users

for Systemic Lupus Erythematosus

1 location in Wilmington

Sponsor: AstraZeneca

Sex: Female·Age: All ages

Code: NCT06659029·Recruiting

Apply to this trial

Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

for Preterm Delivery

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 14+·Accepts healthy volunteers

Code: NCT06980025·Phase 3·Recruiting

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Cognitive Behavioral Theory-assisted Virtual Reality for Chronic CANcer Pain (VR-CAN)

for Cancer

2 locations incl. Washington D.C.

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT07318519·Recruiting

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SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant Families

for Substance Abuse

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 12 - 100·Accepts healthy volunteers

Code: NCT06627764·Recruiting

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A Novel Surgical Irrigation Solution in Post-Mastectomy Reconstruction: Evaluating Xperience™

for Surgical Site Infection

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06649890·Recruiting

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Preventing Type 2 Diabetes in Black Emergent Adult

for Type 2 Diabetes Mellitus

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06848244·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib

for Multiple Myeloma

Drug: Daratumumab

8 locations incl. Denver

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06892522·Phase 1, Phase 2·Recruiting

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Stone and Laser Therapies Post-Market Study (SALT)

for Benign Prostate Hypertrophy(BPH)

5 locations incl. Phoenix

Sponsor: Boston Scientific Corporation

Sex: All·Age: All ages

Code: NCT06982235·Recruiting

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PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

for Hematologic Malignancies

11 locations incl. Duarte

Sponsor: Pulmotect, Inc.

Sex: All·Age: 18+

Code: NCT06665100·Phase 2·Recruiting

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

332 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting

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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

for Ischemic Heart Disease (IHD)

12 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 85

Code: NCT06854458·Recruiting

Apply to this trial

PROGRESS: Precision Oncology Using Genomic Reflexive Evaluations for Study Selection and Survival

for Solid Tumor Malignancies

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06896162·Recruiting

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ONC-LEUK-2406: The Impact of Systematic Financial Navigation in Acute Myeloid Leukemia

for Acute Myeloid Leukemia

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 64

Code: NCT06945042·Recruiting

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A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

for Heart Failure

29 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 40 - 84

Code: NCT06979362·Phase 2·Recruiting

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Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Low-grade NMIBC

28 locations incl. Homewood

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06995677·Phase 2·Recruiting

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Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

for Moderate Aortic Valve Stenosis

Drug: Ataciguat

66 locations incl. Birmingham

Sponsor: Kardigan, Inc.

Sex: All·Age: 50+

Code: NCT07001800·Phase 2, Phase 3·Recruiting

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A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

86 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 40+

Code: NCT07082738·Phase 2·Recruiting

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Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

for Ulcerative Colitis

Drug: Tirzepatide

37 locations incl. Dothan

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 70

Code: NCT06937086·Phase 3·Recruiting

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Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

for Crohn's Disease

Drug: Tirzepatide

35 locations incl. Dothan

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 70

Code: NCT06937099·Phase 3·Recruiting

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A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

for Inflammatory Bowel Disease (IBD)

46 locations incl. Birmingham

Sponsor: Mirador Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT07113522·Phase 2·Recruiting

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Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers

for Diabetic Foot Ulcer (DFU)

18 locations incl. Tucson

Sponsor: LifeNet Health

Sex: All·Age: 21 - 80

Code: NCT07116876·Recruiting

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Identifying and Treating Depression in the Orthopaedic Trauma Population

for Depression

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05976347·Phase 4·Recruiting

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REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

for Venous Thromboembolism (VTE)

19 locations incl. Sheffield

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07015905·Phase 3·Recruiting

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Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

for Heart Failure With Preserved Ejection Fraction

106 locations incl. Birmingham

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07037459·Phase 3·Recruiting

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Safety Study of Viaskin® Peanut Patch in Peanut-Allergic Children 1 Through 3 Years of Age (COMFORT Toddlers)

for Allergy

56 locations incl. Birmingham

Sponsor: DBV Technologies

Sex: All·Age: 1 - 3

Code: NCT07003919·Phase 3·Recruiting

Apply to this trial

Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

for Soft Tissue Lesion

10 locations incl. Gilbert

Sponsor: Galvanize Therapeutics, Inc.

Sex: All·Age: 18 - 100

Code: NCT05851430·Recruiting

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Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

149 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting

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Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

for Hidradenitis Suppurativa

Drug: Ruxolitinib

59 locations incl. Phoenix

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06959225·Phase 3·Recruiting

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Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)

for Pulmonary Disease, Chronic Obstructive

Drug: Depemokimab

55 locations incl. Sheffield

Sponsor: GlaxoSmithKline

Sex: All·Age: 40 - 80

Code: NCT06961214·Phase 3·Recruiting

Apply to this trial

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701682·Phase 2·Recruiting

Apply to this trial

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

for Rheumatoid Arthritis

52 locations incl. Peoria

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06972446·Phase 2·Recruiting

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

24 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting

Apply to this trial

Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery

for Frailty

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 65+

Code: NCT06988176·Recruiting

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A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for Graves' Disease

Drug: IMVT-1402

33 locations incl. Tucson

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 75

Code: NCT07018323·Phase 2·Recruiting

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Brain-Gut Yoga for Functional Dyspepsia and Gastroparesis (FD-GP)

for Functional Dyspepsia

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06732453·Recruiting

Apply to this trial

The Vanguard Study: Testing a New Way to Screen for Cancer

for Bladder Carcinoma

37 locations incl. Pleasanton

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06995898·Recruiting

Apply to this trial

Feasibility of an ADAPTive Intervention to Improve Food Security and Maternal-Child Health

for Food Insecurity

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06942598·Recruiting

Apply to this trial

A Study to Investigate the Efficacy and Safety of Bemdaneprocel in Adults Who Have Parkinson's Disease

for Parkinsons Disease (PD)

31 locations incl. Sun City

Sponsor: BlueRock Therapeutics

Sex: All·Age: 45 - 75

Code: NCT06944522·Phase 3·Recruiting

Apply to this trial

Deflated and Inflated Cuff Endotracheal Extubations

for Anesthesia Airway Management

1 location in Marine Corps Base Camp Lejeune

Sponsor: Naval Medical Center Camp Lejeune

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06990308·Enrolling By Invitation