Identifying and Treating Depression in the Orthopaedic Trauma Population

Conditions

• Depression

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Fluoxetine 20 MG — DRUG
  Fluoxetine 20 mg once daily
• Duloxetine 30 MG — DRUG
  Duloxetine 30 mg once daily
• Observation — OTHER
  Referral to behavioral health and resources for addressing depressive symptoms

Study Details

The goal of this trial is to pilot a way for orthopaedic surgeons to safely screen for depression and provide treatment for depression with medication. The main questions it aims to answer are: 1. What are the outcomes of patients who screen positive for depressive symptoms and are prescribed either an Selective serotonin reuptake inhibitors (SSRI) or serotonin and norepinephrine reuptake inhibitors (SNRI). 2. What are the outcomes of patients who screen positive for depressive symptoms and choose not to pursue treatment with medication?

Key Dates

Start date

Jun 25, 2025

Status verified

Apr 2026

Primary completion

May 31, 2027

Completion

May 31, 2027

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Selective serotonin reuptake inhibitors (SSRI)
  Fluoxetine, 20mg once daily
• Experimental: serotonin and norepinephrine reuptake inhibitors (SNRI)
  Duloxetine, 30mg once daily
• Other: Observational
  Referral to behavioral health per standard practice and provision of resources for strategices to address depressive symptoms.

Primary Outcome Measure

Depressive Symptom Scores [ Time Frame: Baseline ]

Central Contacts

• Erica Grochowski, MPH
  704-403-4980
  [email protected]

Locations (1)

Find similar trials in Winston-Salem, NC

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