Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,587 clinical trials

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"F!reF!ghterF!t": Lifestyle Coaching Interventions for Obese Firefighters (FireFit)

for Obesity and Obesity-related Medical Conditions

1 location in Sommerville

Sponsor: Cambridge Health Alliance

Sex: Male·Age: 18 - 60

Code: NCT06890975·Not Yet Recruiting

A Study of TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

for Alpha-1 Antitrypsin Deficiency (AATD)

2 locations incl. Boston

Sponsor: Tessera Therapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT07227207·Phase 1, Phase 2·Recruiting

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A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for KRAS-mutant Non-small Cell Lung Cancer (NSCLC)

7 locations incl. Sarasota

Sponsor: Kestrel Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07458347·Phase 1·Recruiting

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A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

for Lymphoma, Non-Hodgkin's

Drug: LY4584180

21 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07226843·Phase 1·Recruiting

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A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

for Diabetes Mellitus, Type 2

Drug: NNC0662-0419

23 locations incl. Lancaster

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18 - 75

Code: NCT07415954·Phase 2·Recruiting

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A Study to Investigate the Safety of DSP-3077 After a Unilateral Eye Injection in Male and Female Participants 18 Years of Age or Older With Retinitis Pigmentosa

for Retinitis Pigmentosa

2 locations incl. Boston

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT06891885·Phase 1, Phase 2·Recruiting

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EncompaSSc: Evaluation of MTX-474 in Participants With Diffuse Cutaneous Systemic Sclerosis (dcSSc)

for Diffuse Cutaneous Systemic Sclerosis

6 locations incl. Newport Beach

Sponsor: Mediar Therapeutics

Sex: All·Age: 18+

Code: NCT07287670·Phase 2·Recruiting

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Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy

for Muscle Mass and Strength

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT07400419·Recruiting

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Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia

for RPS19 Deficient Diamond-Blackfan Anemia

2 locations incl. Stanford

Sponsor: Apriligen, Inc.

Sex: All·Age: 2 - 18

Code: NCT07476183·Phase 1·Recruiting

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Increasing Resiliency Among Early Post-Treatment Lymphoma Survivors

for Lymphoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07014293·Not Yet Recruiting

IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens

for Infertility

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT07074015·Recruiting

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Development of a Psychosocial Intervention to Reduce Post Traumatic Stress in Young Adult Survivors of Cancer

for Post-traumatic Stress Symptoms

1 location in Boston

Sponsor: Zeba Ahmad, Ph.D.

Sex: All·Age: 18 - 39

Code: NCT07160933·Not Yet Recruiting

Mechanisms Of Orbitofrontal Stimulation in Depression

for Major Depressive Disorder (MDD)

1 location in Boston

Sponsor: Subha Subramanian

Sex: All·Age: 18 - 65

Code: NCT07230990·Recruiting

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ELDORADO: Elranatamab Versus Daratumumab in Combination With RVd Lite for Newly Diagnosed Transplant Ineligible/Deferred Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07247097·Phase 2·Not Yet Recruiting

An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)

for Indolent Systemic Mastocytosis

1 location in Chestnut Hill

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT07264959·Recruiting

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Reference Range Study for the Quantra System With the QPlus Cartridge in Pediatric Patients

for Pediatric

3 locations incl. Los Angeles

Sponsor: HemoSonics LLC

Sex: All·Age: Up to 17

Code: NCT07447713·Not Yet Recruiting

Effect of FB301 on Vaginal Bacterial Profile in Women With Asymptomatic Vaginal Dysbiosis Undergoing a Mock Frozen Embryo Transfer Cycle

for Vaginal Dysbiosis

1 location in Waltham

Sponsor: Freya Biosciences ApS

Sex: Female·Age: 18 - 40

Code: NCT07453069·Phase 2·Not Yet Recruiting

Autus Valve Continued Access Study (CAS)

for Congenital Heart Disease

10 locations incl. Los Angeles

Sponsor: Autus Valve Technologies, Inc.

Sex: All·Age: 18 Months - 16

Code: NCT07466745·Not Yet Recruiting

Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia

for Osteopenia

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 50+

Code: NCT07473713·Phase 1·Recruiting

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Lifestyle Change Implementation Research Network at PRC at UMass Chan

for GLP - 1

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07481305·Not Yet Recruiting

A Study of Uveitis in Children <18 Years of Age

for Uveitis

4 locations incl. Boston

Sponsor: Jaeb Center for Health Research

Sex: All·Age: Up to 17

Code: NCT07518134·Recruiting

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A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma

for Asthma

11 locations incl. Bakersfield

Sponsor: AstraZeneca

Sex: All·Age: 4 - 11

Code: NCT07525375·Phase 2·Recruiting

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A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)

for Alopecia Areata

Drug: LY4005130

9 locations incl. Fremont

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 50

Code: NCT07533006·Phase 2·Recruiting

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A Study of LY4005130 in Adult Participants With Non-Segmental Vitiligo

for Vitiligo

Drug: LY4005130

18 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07533019·Phase 2·Recruiting

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Remote Monitoring and Symptom Management Digital Application

for Breast Cancer (Locally Advanced or Metastatic)

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT07553572·Recruiting

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A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

for Obesity

Drug: NNC0487-0111

19 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07481630·Phase 3·Recruiting

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The Effectiveness and Acceptability of Formal Versus Informal Mindful Self-Compassion for Adolescents

for Coping

1 location in Malden

Sponsor: Cambridge Health Alliance

Sex: All·Age: 14 - 19·Accepts healthy volunteers

Code: NCT07513220·Recruiting

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LYmph Node eXamination in Cat Allergen Immunotherapy

for Allergy

1 location in Boston

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 45

Code: NCT07447869·EARLY_Phase 1·Recruiting

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Menopausal HT for Women Living With HIV (HoT)

for HIV Infection

23 locations incl. Birmingham

Sponsor: Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

Sex: Female·Age: 40 - 60

Code: NCT06856174·Phase 4·Recruiting

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Fall Risk Intervention for Stroke

for Stroke

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 45 - 85

Code: NCT07349030·Recruiting

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A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

for Solid Tumors

Drug: INCB161734

68 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07522073·Phase 3·Recruiting

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Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

for Ewing Sarcoma

4 locations incl. Los Angeles

Sponsor: Amgen

Sex: All·Age: 2+

Code: NCT07297979·Phase 1·Recruiting

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

22 locations incl. Birmingham

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting

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A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine

for Lyme Disease

19 locations incl. Bangor

Sponsor: Pfizer

Sex: All·Age: 7+·Accepts healthy volunteers

Code: NCT07500506·Phase 3·Recruiting

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A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively

for Schizophrenia

Drug: KarXT

19 locations incl. Anaheim

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 5 - 17

Code: NCT07424404·Phase 3·Recruiting

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Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening

for Lung Cancer Screening

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 50 - 77

Code: NCT07517692·Enrolling By Invitation

A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1

for Narcolepsy Type 1

Drug: ALKS 2680

15 locations incl. Los Angeles

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT07455383·Phase 3·Recruiting

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Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study

for Robotic Surgery

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07277244·Enrolling By Invitation

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

for Post Traumatic Stress Disorder

26 locations incl. Little Rock

Sponsor: Transcend Therapeutics

Sex: All·Age: 18+

Code: NCT07456696·Phase 3·Recruiting

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A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

11 locations incl. Jonesboro

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting

Apply to this trial