A Study of LY4005130 in Adult Participants With Severe Alopecia Areata (Hair Loss)

Part of paid clinical trials in Fremont, California.

Sponsor
Eli Lilly and Company
Study ID
NCT07533006
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • LY4005130 — DRUG
    Administered IV
  • Placebo — DRUG
    Administered IV

Study Details

The purpose of this study is to evaluate how well LY4005130 works in participants with severe alopecia areata (hair loss) when compared with placebo, and how well it's tolerated and what side effects may occur. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study drug will be administered intravenously (IV) (into a vein in the arm). The study will last approximately 48 weeks, including screening.

Key Dates

Start date
Apr 14, 2026
Status verified
Jun 2026
Primary completion
Jun 30, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: LY4005130
    LY4005130 administered intravenously (IV)
  • Placebo Comparator: Placebo
    Placebo administered IV

Primary Outcome Measure

Percentage of Participants Achieving an Absolute Severity of Alopecia Tool (SALT) Less than or Equal to (≤) 20 [ Time Frame: Week 24 ]

Central Contacts

  • Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
    1-317-615-4559
    [email protected]
  • Physicians interested in becoming principal investigators please contact
    [email protected]

Locations (9)

FacilityCityStateZIPSite coordinators
Center For Dermatology Clinical Research, Inc.FremontCalifornia94538
510-797-0140
Sunil Dhawan (PRINCIPAL_INVESTIGATOR)
Northridge Clinical TrialsNorthridgeCalifornia91325
818-350-7482
Navid Ezra (PRINCIPAL_INVESTIGATOR)
Cura Clinical Research - Santa Clarita - Kelly Johnson ParkwaySanta ClaritaCalifornia91355
833-525-2872
Bernard Raskin (PRINCIPAL_INVESTIGATOR)
Health Clinical Research, LLCCutler BayFlorida33189
786-280-1977
Soroush Aghigh (PRINCIPAL_INVESTIGATOR)
Brigham and Women's HospitalBostonMassachusetts02115
617-732-4918
Arash Mostaghimi (PRINCIPAL_INVESTIGATOR)
Revival Research Institute, LLCTroyMichigan48084
248-590-0298
Ali Moiin (PRINCIPAL_INVESTIGATOR)
StracskinPortsmouthNew Hampshire03801
617-833-9995
Abel Jarell (PRINCIPAL_INVESTIGATOR)
Texas Dermatology and Laser Specialists - San Antonio - South New Braunfels AvenueSan AntonioTexas78235
210-852-2779
John Browning (PRINCIPAL_INVESTIGATOR)
Jordan Valley Dermatology & Research CenterSouth JordanUtah84095
Douglass Forsha (PRINCIPAL_INVESTIGATOR)

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