Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Gamma Frequency Stimulation in Individuals With Down Syndrome

for Down Syndrome

1 location in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 25 - 65·Accepts healthy volunteers

Code: NCT05196984·Recruiting

Apply to this trial

Estrogen Administration for the Treatment of NASH in Postmenopausal Women

for NASH - Nonalcoholic Steatohepatitis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45 - 70

Code: NCT04833140·Phase 3·Recruiting

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FDG an Myocardial Infarction: The PIAF Trial

for History of Myocardial Infarction

1 location in Boston

Sponsor: International Atomic Energy Agency

Sex: All·Age: 18 - 80

Code: NCT05138718·Recruiting

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(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

for Indolent Systemic Mastocytosis

14 locations incl. Birmingham

Sponsor: Blueprint Medicines Corporation

Sex: All·Age: 18+

Code: NCT04910685·Phase 2, Phase 3·Recruiting

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Promoting Well-being and Health in Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04829617·Recruiting

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Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)

for Iron-deficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04945707·Phase 4·Recruiting

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HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

for Hip Fractures

19 locations incl. Chandler

Sponsor: Population Health Research Institute

Sex: All·Age: 45+

Code: NCT04743765·Recruiting

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Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for Breast Cancer

7 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT03990896·Phase 2·Recruiting

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IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures

for Cancer Metastatic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 21+

Code: NCT04842266·Recruiting

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CLN-049 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

for Relapsed/Refractory Acute Myeloid Leukemia (AML)

11 locations incl. Birmingham

Sponsor: Cullinan Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05143996·Phase 1·Recruiting

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Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents

for Rumination

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 13 - 18·Accepts healthy volunteers

Code: NCT04697966·Recruiting

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Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

for Relapsed Classic Hodgkin Lymphoma

Drug: Nivolumab

5 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04561206·Phase 2·Recruiting

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Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

for Renal Pelvis and Ureter Urothelial Carcinoma

Drug: Durvalumab

258 locations incl. Kingman

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04628767·Phase 2, Phase 3·Recruiting

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Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

for Breast Cancer, NOS

347 locations incl. Fairbanks

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 39

Code: NCT05108298·Recruiting

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Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

for Healthy Children

5 locations incl. Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 6 Months - 8·Accepts healthy volunteers

Code: NCT04639830·Recruiting

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(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

for Advanced Systemic Mastocytosis (AdvSM)

14 locations incl. Birmingham

Sponsor: Cogent Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04996875·Phase 2·Recruiting

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting

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Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)

for Acute Stroke

35 locations incl. Fairhope

Sponsor: DiaMedica Therapeutics Inc

Sex: All·Age: 18 - 90

Code: NCT05065216·Phase 2, Phase 3·Recruiting

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Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine

for Chronic Kidney Diseases

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT04500665·Phase 2·Recruiting

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The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 45 - 65

Code: NCT04505865·Recruiting

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Desara ® One Single Incision Sling 522 Study

for Stress Urinary Incontinence

15 locations incl. Phoenix

Sponsor: Caldera Medical, Inc.

Sex: Female·Age: 18+

Code: NCT04772131·Recruiting

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American Lung Association (ALA) Lung Health Cohort

for Lung Diseases

37 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT04543461·Recruiting

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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for Solid Tumor, Adult

16 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT04981119·Recruiting

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First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)

for Advanced Non-small Cell Lung Cancer

11 locations incl. Gilbert

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT05099172·Phase 1, Phase 2·Recruiting

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A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for Metastatic Colorectal Cancer

35 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT04929223·Phase 1·Recruiting

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A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

for Endometrial Cancer

21 locations incl. Duarte

Sponsor: Alliance Foundation Trials, LLC.

Sex: Female·Age: 18+

Code: NCT04486352·Phase 1, Phase 2·Recruiting

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

19 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

14 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting

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Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

for Interstitial Lung Disease

14 locations incl. Phoenix

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04930289·Enrolling By Invitation

US National OCS Liver Perfusion (OLP) Registry

for Liver Transplant

22 locations incl. Birmingham

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT05940857·Recruiting

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Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study

for Tuberous Sclerosis Complex

11 locations incl. Birmingham

Sponsor: Darcy Krueger

Sex: All·Age: 1 Day - 6 Months

Code: NCT05104983·Phase 2·Recruiting

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Using Transcranial Magnetic Stimulation (TMS) to Understand Hallucinations in Schizophrenia

for Schizophrenia

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 55

Code: NCT05343598·Recruiting

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PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

65 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting

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STRIVE Post-Market Registry Study

for Emphysema

14 locations incl. Phoenix

Sponsor: Olympus Corporation of the Americas

Sex: All·Age: 18+

Code: NCT04302272·Recruiting

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Scalp Cooling in MBC

for Metastatic Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04986579·Phase 2·Recruiting

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TriPRIL CAR T Cells in Multiple Myeloma

for Multiple Myeloma

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT05020444·Phase 1·Recruiting

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fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

for Pain, Postoperative

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 8 - 35·Accepts healthy volunteers

Code: NCT04439552·Recruiting

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Skills to Enhance Positivity in Suicidal Youth

for Suicide, Attempted

3 locations incl. Boston

Sponsor: Brown University

Sex: All·Age: 12 - 60

Code: NCT04994873·Recruiting

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XACT ACE Observational Registry

for Tumors

1 location in Burlington

Sponsor: Xact Robotics Ltd.

Sex: All·Age: 18+

Code: NCT04950959·Recruiting

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iCanCope With Post-Operative Pain (iCanCope PostOp)

for Pain, Chronic

1 location in Boston

Sponsor: The Hospital for Sick Children

Sex: All·Age: 12 - 18

Code: NCT05382962·Recruiting

Apply to this trial