fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Boston Children's Hospital
Study ID
NCT04439552
Status
Recruiting
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Conditions

  • Cornea
  • Cornea Injury
  • Keratoconus
  • Pain, Acute
  • Pain, Chronic
  • Pain, Postoperative
  • Surgical Injury
  • Surgical Wound

Eligibility Criteria

Sex
ALL
Age
8 Years - 35 Years
Healthy Volunteers
Accepted

Study Details

Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).

Key Dates

Start date
Oct 4, 2021
Status verified
Dec 2025
Primary completion
Aug 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: CXL group
    Patients who are about to undergo a corneal cross-linking (CXL) surgery to treat keratoconus.
  • Arm: Control group
    Healthy volunteers age and sex matched to the CXL group.

Primary Outcome Measure

Neural activity related to pain. [ Time Frame: 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Boston Children's HospitalBostonMassachusetts02115
Nicholas J Pondelis, BA
[email protected]
617-919-1895

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By research site
Boston Children's Hospital· Boston, MA

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