Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population

for Anxiety Disorders

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+

Code: NCT04895995·Recruiting

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myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home

for COPD

25 locations incl. Birmingham

Sponsor: Temple University

Sex: All·Age: 30+

Code: NCT05204888·Recruiting

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Intermittent Fasting for NAFLD in Adults

for Fatty Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04899102·Recruiting

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An Ethical Approach to Detecting Covert Consciousness

for Disorder of Consciousness

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05010265·Recruiting

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Real-time Symptom Monitoring Using ePROs to Prevent Adverse Events During Care Transitions

for Multiple Chronic Conditions

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05282654·Recruiting

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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

for HER2-positive Advanced Solid Tumor

Drug: DB-1303/BNT323

35 locations incl. Cerritos

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT05150691·Phase 1, Phase 2·Recruiting

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CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

for Diffuse Midline Glioma, H3 K27-Altered

34 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 21

Code: NCT04870944·Phase 1, Phase 2·Recruiting

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Improving Visual Field Deficits With Noninvasive Brain Stimulation

for Visual Field Defect, Peripheral

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 80

Code: NCT05085210·Recruiting

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Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for Advanced Solid Tumor

27 locations incl. Tucson

Sponsor: Synthekine

Sex: All·Age: 18+

Code: NCT05098132·Phase 1, Phase 2·Recruiting

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Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

for Schizophrenia

18 locations incl. Phoenix

Sponsor: Reviva Pharmaceuticals

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05184335·Phase 3·Recruiting

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Resilience and Equity in Aging, Cancer, and Health (REACH)

for Gastric Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 70+

Code: NCT04674267·Recruiting

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A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)

for DLBCL

26 locations incl. Glendale

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05139017·Phase 2, Phase 3·Recruiting

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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

for AMD

107 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 50 - 89

Code: NCT05407636·Phase 3·Recruiting

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Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism

for Opioid Use

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT04798469·Phase 2·Recruiting

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rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

for Diffuse Intrinsic Pontine Glioma

3 locations incl. Orange

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 Months - 18

Code: NCT04943848·Phase 1·Recruiting

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Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

for Type 2 Diabetes Mellitus

79 locations incl. Huntsville

Sponsor: Prokidney

Sex: All·Age: 30 - 80

Code: NCT05099770·Phase 3·Recruiting

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Cannabidiol for Reduction of Brain Neuroinflammation

for Back Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT05066308·Phase 2·Recruiting

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Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II

for Refractory Angina

70 locations incl. Phoenix

Sponsor: Shockwave Medical, Inc.

Sex: All·Age: 18+

Code: NCT05102019·Recruiting

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A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

for Locally Advanced Solid Tumor

20 locations incl. Orange

Sponsor: Nuvalent Inc.

Sex: All·Age: 12+

Code: NCT05118789·Phase 1, Phase 2·Recruiting

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Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract

for Cataract

9 locations incl. Huntington Beach

Sponsor: EyePoint Pharmaceuticals, Inc.

Sex: All·Age: Up to 3

Code: NCT05191706·Phase 4·Recruiting

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The PROGRAM-study: Awake Mapping Versus Asleep Mapping Versus No Mapping for Glioblastoma Resections

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Erasmus Medical Center

Sex: All·Age: 18 - 90

Code: NCT04708171·Recruiting

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The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

for Glioblastoma

2 locations incl. San Francisco

Sponsor: Jasper Gerritsen

Sex: All·Age: 18 - 90

Code: NCT06118723·Recruiting

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Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression

for Major Depressive Disorder

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05630963·Recruiting

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Stereotactic Body Radiotherapy (SBRT) for Early Treatment of Oligometastatic Adenoid Cystic Carcinoma: The SOLAR Trial

for Adenoid Cystic Carcinoma

5 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04883671·Recruiting

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Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemia

for Myeloid Leukemia, Philadelphia Positive

8 locations incl. Indianapolis

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 1 - 17

Code: NCT04925479·Phase 1, Phase 2·Recruiting

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HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome

for Angelman Syndrome

6 locations incl. San Diego

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 0 - 50

Code: NCT05127226·Phase 1, Phase 2·Recruiting

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Triage Survey for Psychiatry Research Eligibility

for Major Depressive Disorder

6 locations incl. Boston

Sponsor: Adams Clinical

Sex: All·Age: 18+

Code: NCT05800925·Recruiting

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Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD

for Neovascular Age-Related Macular Degeneration (nAMD)

16 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: All ages

Code: NCT05210803·Enrolling By Invitation

ViTAA Registry Pre- and Post-Operative Monitoring for Endovascular Aortic Aneurysm Repair and Serial Monitoring for AAA

for Abdominal Aortic Aneurysms

4 locations incl. Birmingham

Sponsor: ViTAA Medical Solutions

Sex: All·Age: 18+

Code: NCT05004051·Recruiting

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Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells

for Solid and Hematological Malignancies

49 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: All ages

Code: NCT05041309·Enrolling By Invitation

Aspiration in Acute Respiratory Failure Survivors 2

for Dysphagia

5 locations incl. Stanford

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT05108896·Recruiting

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TRAjectories and CLinical ExpeRiences of ICD Therapy Study

for Implantable Defibrillator User

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 65+

Code: NCT05116176·Enrolling By Invitation

Long-term Follow-up Study to Evaluate Durability of Treatment Response in Previous Bepirovirsen Study Participants (B-Sure)

for Hepatitis B

Drug: Bepirovirsen

3 locations incl. Sacramento

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT04954859·Phase 2·Recruiting

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

46 locations incl. Phoenix

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting

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Advanced SPinal Innovations With Robotics and Enabling Technology Registry

for Spine Deformity

10 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 21·Accepts healthy volunteers

Code: NCT05071144·Recruiting

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JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

for Carcinoma, Squamous Cell

26 locations incl. Birmingham

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 60+

Code: NCT04892173·Phase 3·Recruiting

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

20 locations incl. Birmingham

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting

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4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

for Neovascular (Wet) Age-Related Macular Degeneration

24 locations incl. Phoenix

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT05197270·Phase 1, Phase 2·Recruiting

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

24 locations incl. Tucson

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting

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A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

for Stereotypical Prolonged Seizures

66 locations incl. Phoenix

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12+

Code: NCT05077904·Phase 3·Recruiting

Apply to this trial