Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Optimizing Feedback-based Learning in Children With Developmental Language Disorder

for Developmental Language Disorder

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 8 - 12

Code: NCT05678634·Recruiting

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AZD0120 in Relapsed/Refractory Multiple Myeloma (DURGA-1)

for Relapsed/Refractory Multiple Myeloma

36 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05850234·Phase 1, Phase 2·Recruiting

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Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

for Acneiform Eruption Due to Chemical

9 locations incl. Irvine

Sponsor: Hoth Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05639933·Phase 2·Recruiting

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A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

for Acute Myeloid Leukemia

Drug: Venetoclax

44 locations incl. Phoenix

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05735184·Phase 1·Recruiting

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Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy

for Pulmonary Embolism

40 locations incl. Birmingham

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05591118·Phase 3·Recruiting

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Cognitive Neurology Unit Clinical Registry

for Alzheimer Disease

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 50 - 95

Code: NCT05925621·Recruiting

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Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients

for Psoriatic Arthritis

Drug: Guselkumab

14 locations incl. Loxahatchee Groves

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT05669833·Phase 3·Recruiting

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The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

for Lymphedema, Breast Cancer

4 locations incl. New Haven

Sponsor: University Hospital, Basel, Switzerland

Sex: All·Age: 18+

Code: NCT05890677·Recruiting

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

for Locally Advanced Lung Non-Small Cell Carcinoma

470 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05624996·Phase 3·Recruiting

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A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

for Cerebral Adrenoleukodystrophy (cALD)

Drug: Leriglitazone

6 locations incl. Palo Alto

Sponsor: Minoryx Therapeutics, S.L.

Sex: Male·Age: 18+

Code: NCT05819866·Phase 3·Recruiting

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A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

18 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting

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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

for Non-muscle-invasive Bladder Cancer

20 locations incl. Mesa

Sponsor: SURGE Therapeutics

Sex: All·Age: 18+

Code: NCT05710848·Phase 1, Phase 2·Recruiting

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Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial

for Glaucoma

7 locations incl. San Francisco

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05924477·Recruiting

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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

for Psychosis Associated With Alzheimer's Disease

Drug: KarXT

147 locations incl. Homewood

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT05980949·Phase 3·Recruiting

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Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory T-cell Lymphoma

for T-Cell Lymphoma

2 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05313243·Phase 2·Recruiting

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Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for Metastatic Malignant Solid Neoplasm

22 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687110·Phase 1·Recruiting

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Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

Drug: Inebilizumab

4 locations incl. La Jolla

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT05549258·Phase 2·Recruiting

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Rescue Pharmacotherapy for OSA

for Obstructive Sleep Apnea

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT05293600·Phase 1, Phase 2·Recruiting

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Impact of Cognitive Behavioral Therapy on PTSD-CVD Link

for Posttraumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT06429293·Recruiting

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Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

for Multiple Myeloma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05706766·Recruiting

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Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

22 locations incl. Tucson

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting

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DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

14 locations incl. Birmingham

Sponsor: DynamiCure Biotechnology

Sex: All·Age: 18+

Code: NCT05785754·Phase 1·Recruiting

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A Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease (COPD)

for Chronic Obstructive Pulmonary Disease

68 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 40 - 90

Code: NCT05878769·Phase 3·Recruiting

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Lupus Landmark Study: A Prospective Registry and Biorepository

for Systemic Lupus Erythematosus (SLE)

19 locations incl. Birmingham

Sponsor: Lupus Research Alliance

Sex: All·Age: 18 - 110

Code: NCT05934149·Recruiting

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A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations

for Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

9 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: Up to 17

Code: NCT05788536·Phase 1, Phase 2·Recruiting

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The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency

for Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency

5 locations incl. San Diego

Sponsor: Inozyme Pharma

Sex: All·Age: Up to 1

Code: NCT05734196·Phase 1·Recruiting

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Symptom Monitoring in Hemodialysis

for End Stage Kidney Disease

1 location in Waltham

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05738330·Recruiting

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A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Iberdomide

44 locations incl. Aurora

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05827016·Phase 3·Recruiting

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Epcoritamab and Rituximab for First-line Follicular Lymphoma

for Follicular Lymphoma

Drug: Epcoritamab

6 locations incl. Boston

Sponsor: Reid Merryman, MD

Sex: All·Age: 18+

Code: NCT05783609·Phase 2·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

for Hidradenitis Suppurativa

Drug: Upadacitinib

87 locations incl. Birmingham

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT05889182·Phase 3·Recruiting

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Surgical Treatments for Postamputation Pain

for Residual Limb Pain

3 locations incl. Chicago

Sponsor: Prometei Pain Rehabilitation Center

Sex: All·Age: 18+

Code: NCT05009394·Recruiting

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Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

for Stress Disorders, Post-Traumatic

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05853627·Phase 4·Recruiting

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DFC 004 Biomarkers for Active Diabetic Foot Ulcers

for Diabetic Foot Ulcer

8 locations incl. Tucson

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT06104969·Recruiting

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Mechanisms of Anabolic Osteoporosis Therapy

for Osteoporosis, Postmenopausal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45+

Code: NCT05688969·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

for Relapsing Multiple Sclerosis

36 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT05877963·Phase 3·Recruiting

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

18 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting

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Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension

for Postpartum Hypertension

3 locations incl. New Haven

Sponsor: Yale University

Sex: Female·Age: 18+

Code: NCT05884190·Recruiting

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Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

for Non Small Cell Lung Cancer

13 locations incl. Santa Monica

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05887492·Phase 1, Phase 2·Recruiting

Apply to this trial