Paid Clinical Trials in Massachusetts

Massachusetts has 3,586 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for AML

38 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06001788·Phase 1·Recruiting

Apply to this trial

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

34 locations incl. Little Rock

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting

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An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for Emphysema, Pulmonary

18 locations incl. Phoenix

Sponsor: Pulmonx Corporation

Sex: All·Age: 40 - 80

Code: NCT06035120·Recruiting

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A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

for Multiple Myeloma

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06121843·Phase 1·Recruiting

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Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

for Diabetes

21 locations incl. Dothan

Sponsor: Sonavex, Inc.

Sex: All·Age: 18 - 84

Code: NCT06190717·Recruiting

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

234 locations incl. Athens

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

CIML NK Cells With Venetoclax for AML

for Acute Myeloid Leukemia

Drug: Venetoclax

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06152809·Phase 1·Recruiting

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A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

for Myotonic Dystrophy Type 1 (DM1)

8 locations incl. San Carlos

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 64

Code: NCT06185764·Phase 1, Phase 2·Recruiting

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A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

for Multiple Myeloma

Drug: Elranatamab

34 locations incl. Coral Gables

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06215118·Phase 1·Recruiting

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Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT06253104·Recruiting

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Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency

for Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

6 locations incl. Birmingham

Sponsor: Medicure

Sex: All·Age: All ages

Code: NCT04706013·Phase 3·Recruiting

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

21 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting

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Cognitive Training to Enhance Brain Concordance During Acupuncture

for Fibromyalgia

3 locations incl. Charlestown

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06157866·Recruiting

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PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

for Head and Neck Cancer

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06239220·Phase 2·Recruiting

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A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

for Advanced Solid Tumor

20 locations incl. Irvine

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06244485·Phase 1·Recruiting

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Low Sodium Oxybate in Patients With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

4 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT05837091·Phase 4·Recruiting

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Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio

for Bile Duct Cancer

Drug: Durvalumab

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT05655949·Phase 2·Recruiting

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Tocilizumab in Lung Transplantation

for Lung Transplant

Drug: Tocilizumab

21 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 75

Code: NCT06033196·Phase 2·Recruiting

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A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4

for Congenital Myasthenic Syndrome

6 locations incl. Sacramento

Sponsor: argenx

Sex: All·Age: 2+

Code: NCT06078553·Recruiting

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Behavioral Activation for Independence in Older Veterans

for Functional Independence

1 location in Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+

Code: NCT05493241·Recruiting

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RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

for Prostate Cancer

Drug: Relugolix

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT05765500·Phase 2·Recruiting

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

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A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

for Ovarian Cancer

14 locations incl. Denver

Sponsor: OnCusp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06234423·Phase 1·Recruiting

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

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Cognitive Function and Affective Regulation in Meditators

for Cognitive Function and Affective Regulation

1 location in Boston

Sponsor: Balachundhar Subramaniam

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07546786·Recruiting

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A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

30 locations incl. Daphne

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06095505·Phase 2·Recruiting

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MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

for Multiple Myeloma

Drug: Elranatamab

97 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06152575·Phase 3·Recruiting

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A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

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Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform

for Shwachman-Diamond Syndrome

1 location in Woburn

Sponsor: Shwachman-Diamond Syndrome Alliance Inc

Sex: All·Age: All ages

Code: NCT06999954·Recruiting

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Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

for Metastatic Dedifferentiated Liposarcoma

Drug: Peposertib

16 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05711615·Phase 1·Recruiting

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Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: National Jewish Health

Sex: All·Age: 6+

Code: NCT06262282·Enrolling By Invitation

MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick

for Breast Cancer

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 40+

Code: NCT05968157·Recruiting

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

490 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting

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The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

for Prostate Cancer

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: Male·Age: 55 - 69·Accepts healthy volunteers

Code: NCT05926102·Recruiting

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Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

for Neuromyelitis Optica Spectrum Disorder

6 locations incl. Washington D.C.

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05966467·Recruiting

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Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial

for Lung Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06026111·Recruiting

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Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

for Advanced Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06062745·Phase 1·Recruiting

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Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

5 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858·Recruiting

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A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting

Apply to this trial